INT157

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Context Info
Confidence 0.70
First Reported 1971
Last Reported 2010
Negated 41
Speculated 61
Reported most in Abstract
Documents 790
Total Number 851
Disease Relevance 104.54
Pain Relevance 374.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
pituitary 92
plasma 46
hypothalamus 37
brain 30
neurons 30
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1954 100.00 Very High Very High Very High
agonist 1292 100.00 Very High Very High Very High
narcan 960 100.00 Very High Very High Very High
Morphine 899 100.00 Very High Very High Very High
Opioid 554 100.00 Very High Very High Very High
opiate 544 100.00 Very High Very High Very High
Glutamate 412 100.00 Very High Very High Very High
Enkephalin 323 100.00 Very High Very High Very High
Endogenous opioid 201 100.00 Very High Very High Very High
Neuropeptide 198 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 2187 100.00 Very High Very High Very High
Galactorrhea 175 100.00 Very High Very High Very High
Congenital Anomalies 17 100.00 Very High Very High Very High
Cluster Headache 16 100.00 Very High Very High Very High
Catalepsy 5 100.00 Very High Very High Very High
Cancer 773 99.96 Very High Very High Very High
Pituitary Cancer 390 99.96 Very High Very High Very High
Sleep Disorders 16 99.88 Very High Very High Very High
Personality Disorder 2 99.88 Very High Very High Very High
Aging 53 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of morphine administration on the subsequent stimulation of prolactin (PRL) secretion and the release of dopamine from tuberoinfundibular neurons was examined in this study.
Positive_regulation (stimulation) of Localization (secretion) of PRL in neurons associated with dopamine and morphine
1) Confidence 0.70 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3950867 Disease Relevance 0.15 Pain Relevance 0.61
In conclusion, different responses are induced depending on the type of stress: more intense PRL secretion is induced by restraint and higher hyperglycemia by surgery.
Positive_regulation (induced) of Localization (secretion) of PRL associated with hyperglycemia and stress
2) Confidence 0.70 Published 1996 Journal Life Sci. Section Abstract Doc Link 8606624 Disease Relevance 0.71 Pain Relevance 0.05
Although neither haloperidol nor morphine increased the release of PRL from the isolated anterior pituitary, haloperidol, but not morphine, reversed the inhibition by dopamine of the in vitro release of pituitary PRL.
Neg (neither) Positive_regulation (increased) of Localization (release) of PRL in pituitary associated with dopamine and morphine
3) Confidence 0.70 Published 1978 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 745306 Disease Relevance 0 Pain Relevance 1.28
Our laboratory has demonstrated previously that the ability of opiates to stimulate prolactin (PRL) release during ontogeny precedes the appearance of a PRL response to serotonergic drugs.
Positive_regulation (stimulate) of Localization (release) of PRL associated with opiate
4) Confidence 0.70 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2435887 Disease Relevance 0 Pain Relevance 0.71
There are data indicating that stress-induced prolactin (PRL) release is blunted in the lactating rat like the release of other stress-associated hormones.
Positive_regulation (induced) of Localization (release) of PRL associated with stress
5) Confidence 0.70 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1407378 Disease Relevance 0.20 Pain Relevance 0
Morphine stimulated PRL secretion in adult and neonatal (10-day-old) rats and this increase was blocked with the opiate antagonist naloxone.
Positive_regulation (stimulated) of Localization (secretion) of PRL associated with antagonist, narcan, opiate and morphine
6) Confidence 0.70 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2435887 Disease Relevance 0 Pain Relevance 1.00
In the adult rat, the administration of chronic high-dose morphine has been shown to attenuate the ability of opiates to stimulate PRL secretion.
Positive_regulation (stimulate) of Localization (secretion) of PRL associated with opiate and morphine
7) Confidence 0.70 Published 2003 Journal Dev Psychobiol Section Abstract Doc Link 15027420 Disease Relevance 0 Pain Relevance 0.53
Role of serotonin in opiate-induced prolactin secretion and antinociception in the developing rat.
Positive_regulation (induced) of Localization (secretion) of prolactin associated with pain, antinociception, opiate and serotonin
8) Confidence 0.70 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2435887 Disease Relevance 0 Pain Relevance 1.11
The effects taken into account are: analgesia (tail-pinch test), stimulation of prolactin (PRL) secretion, and inhibition of gastro-intestinal (GI) motility (charcoal meal transit).
Positive_regulation (stimulation) of Localization (secretion) of PRL in tail associated with analgesia
9) Confidence 0.70 Published 1983 Journal Peptides Section Abstract Doc Link 6647121 Disease Relevance 0 Pain Relevance 0.27
In the present studies, the effect of the above-mentioned stressors has been investigated on formalin-induced prolactin (PRL) and corticosterone secretion.
Positive_regulation (induced) of Localization (secretion) of prolactin
10) Confidence 0.70 Published 2007 Journal Neuroendocrinology Section Abstract Doc Link 17556846 Disease Relevance 0.17 Pain Relevance 0
Thus, it is unlikely that changes in dopamine secretion alone can account for the increased release of PRL engendered by cervical stimulation.
Positive_regulation (increased) of Localization (release) of PRL associated with dopamine
11) Confidence 0.70 Published 1979 Journal Endocrinology Section Abstract Doc Link 487998 Disease Relevance 0 Pain Relevance 0.46
Dopamine levels in hypophysial stalk plasma of the rat during surges of prolactin secretion induced by cervical stimulation.
Positive_regulation (induced) of Localization (secretion) of prolactin in plasma associated with dopamine
12) Confidence 0.70 Published 1979 Journal Endocrinology Section Title Doc Link 487998 Disease Relevance 0 Pain Relevance 0.35
Urethane anesthesia, necessary for the surgery attendant to stalk blood collection, did not suppress the surge of PRL secretion induced by cervical stimulation 16-24 h previously.
Neg (not) Positive_regulation (induced) of Localization (secretion) of PRL in blood associated with anesthesia
13) Confidence 0.70 Published 1979 Journal Endocrinology Section Abstract Doc Link 487998 Disease Relevance 0 Pain Relevance 0.38
We investigated this question in the present study by measuring dopamine concentrations in hypophysial stalk blood of the rat during the surgess of PRL secretion induced by cervical stimulation.
Positive_regulation (induced) of Localization (secretion) of PRL in hypophysial stalk associated with dopamine
14) Confidence 0.70 Published 1979 Journal Endocrinology Section Abstract Doc Link 487998 Disease Relevance 0 Pain Relevance 0.34
The effect of melatonin on the prolactin (PRL) release induced by treatment with naloxone, naloxone methyliodide, naltrexone and nalmefene were studied in adult male rats.
Positive_regulation (induced) of Localization (release) of prolactin associated with narcan
15) Confidence 0.70 Published 1995 Journal Endocr. Res. Section Abstract Doc Link 7588425 Disease Relevance 0 Pain Relevance 0.37
Effects of the opiate receptor antagonist naltrexone (NALT, 10 mg/kg) on basal and novel environment stress-induced prolactin (PRL) release were examined in young (3-5 month) and old (22-24 month) male Copenhagen-Fischer 344 rats.
Spec (examined) Positive_regulation (induced) of Spec (examined) Localization (release) of PRL associated with stress, antagonist and opiate
16) Confidence 0.70 Published 1991 Journal Neurobiol. Aging Section Abstract Doc Link 1646967 Disease Relevance 0.40 Pain Relevance 0.15
These results indicate that the role of endogenous opioid peptides (EOP) in regulating basal PRL secretion appears to be diminished, whereas EOP continue to be involved in stress-induced PRL release in the aging animal.
Positive_regulation (induced) of Localization (release) of PRL associated with stress, aging and endogenous opioid
17) Confidence 0.70 Published 1991 Journal Neurobiol. Aging Section Abstract Doc Link 1646967 Disease Relevance 0.65 Pain Relevance 0.18
Melatonin modifies prolactin release induced by opiate antagonists in male rats.
Positive_regulation (induced) of Localization (release) of prolactin associated with antagonist, narcan and opiate
18) Confidence 0.70 Published 1995 Journal Endocr. Res. Section Title Doc Link 7588425 Disease Relevance 0 Pain Relevance 0.77
We found that: the reduction in serotoninergic activity after PCPA administration did not modify serum PRL concentrations; the stimulatory effect of 5-HTP on PRL secretion was not observed before day 16; the effects of 5-HTP or 5-HTP and fluoxetine were similar in intact and orchidectomized males; a significant increase in PRL secretion took place after 8-OH-DPAT administration; the duration of the stimulatory effect of 5-HTP increased after alpha-diol treatment; and pituitary PRL content increased after 5-HTP injection in intact males and decreased in castrated males treated with testosterone or alpha-diol.
Positive_regulation (increase) of Localization (secretion) of PRL in pituitary associated with fluoxetine
19) Confidence 0.70 Published 1994 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7524955 Disease Relevance 0 Pain Relevance 0.24
On the other hand, whereas animals pretreated with ketanserin or LY53857 (both at a dose of 5 mg/kg BW, ip), two specific 5-HT2 receptor antagonists, had no effect on fentanyl-induced PRL secretion, the same treatment significantly blocked 5-HT-induced PRL secretion.
Positive_regulation (induced) of Localization (secretion) of PRL associated with antagonist
20) Confidence 0.70 Published 1989 Journal Endocrinology Section Abstract Doc Link 2551630 Disease Relevance 0 Pain Relevance 0.55

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