INT157020

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.39
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (DDIT3) nucleus (DDIT3) cell cycle (DDIT3)
DNA binding (DDIT3) transcription factor binding (DDIT3)
Anatomy Link Frequency
bone marrow 1
DDIT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
vincristine 2 90.64 High High
corticosteroid 1 88.72 High High
cINOD 1 69.48 Quite High
Inflammation 1 69.00 Quite High
ischemia 1 65.00 Quite High
cytokine 2 34.40 Quite Low
Pain 9 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 11 100.00 Very High Very High Very High
Apoptosis 1 83.00 Quite High
Lymphatic System Cancer 8 81.60 Quite High
Disease 60 81.36 Quite High
Kaposis Sarcoma 9 80.80 Quite High
Viral Meningitis 1 78.88 Quite High
Syndrome 6 73.08 Quite High
INFLAMMATION 1 69.00 Quite High
Neuropathy 2 68.68 Quite High
Cv General 4 Under Development 1 65.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the inhibitory effect of pranoprofen on ER stress-related genes (GRP78 and CHOP) would be mediated through the inhibition of XBP-1 splicing.
Negative_regulation (effect) of CHOP associated with stress
1) Confidence 0.42 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19114067 Disease Relevance 1.23 Pain Relevance 0.14
Azathioprine and bone marrow transplantation have also been attempted, especially following failure of CHOP, but have yielded mixed results. [3]
Negative_regulation (failure) of CHOP in bone marrow
2) Confidence 0.06 Published 2003 Journal BMC Infect Dis Section Body Doc Link PMC212557 Disease Relevance 1.16 Pain Relevance 0.09

General Comments

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