INT157023

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 3.91
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2S1) RNA binding (EIF2S1) nucleus (EIF2S1)
translation (EIF2S1) cytoplasm (EIF2S1)
EIF2S1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 85.16 High High
Inflammation 3 84.68 Quite High
ischemia 3 80.68 Quite High
Disease Link Frequency Relevance Heat
Stress 33 99.98 Very High Very High Very High
Apoptosis 3 98.68 Very High Very High Very High
INFLAMMATION 3 84.68 Quite High
Cv General 4 Under Development 3 80.68 Quite High
Disease 12 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, pranoprofen alone induced eIF2alpha phosphorylation, which was further increased by ER stress.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of eIF2alpha associated with stress
1) Confidence 0.67 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19114067 Disease Relevance 1.29 Pain Relevance 0.15
ER stress-induced phosphorylation of alpha-subunit of eukaryotic initiation factor-2 (eIF2alpha) has been reported to be involved in CHOP induction.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of eIF2alpha associated with stress
2) Confidence 0.49 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19114067 Disease Relevance 1.33 Pain Relevance 0.17
Interestingly, pranoprofen alone induced eIF2alpha phosphorylation, which was further increased by ER stress.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of eIF2alpha associated with stress
3) Confidence 0.49 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19114067 Disease Relevance 1.29 Pain Relevance 0.15

General Comments

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