INT157048

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.31
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mcpt1) extracellular region (Mcpt1) intracellular (Mcpt1)
Anatomy Link Frequency
microglia 2
Mcpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 85 99.24 Very High Very High Very High
tetrodotoxin 7 98.64 Very High Very High Very High
Inflammation 46 97.20 Very High Very High Very High
Morphine 78 90.04 High High
sodium channel 8 84.76 Quite High
Nav1.9 1 84.12 Quite High
nav1.8 1 83.64 Quite High
Nav1.7 1 83.32 Quite High
nav1.3 1 83.00 Quite High
adenocard 1 82.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 52 97.20 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 32 50.00 Quite Low
Diabetes Mellitus 29 50.00 Quite Low
Insulin Resistance 8 50.00 Quite Low
Impaired Glucose Tolerance 6 50.00 Quite Low
Hyperlipidemia 2 50.00 Quite Low
Obesity 33 27.76 Quite Low
Metabolic Disorder 6 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, Rx had a more effective inhibitory effect than Rosiglitazone on the secretion of MCP-1 and IL-6 (figure 3a, b).
Regulation (effect) of Localization (secretion) of MCP-1
1) Confidence 0.18 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.31 Pain Relevance 0.24
Furthermore, the release of MCP-1 and IL-6 is highly calcium-dependent.
Regulation (dependent) of Localization (release) of MCP-1
2) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.82
Phenytoin attenuated by approximately 50% the release of IL-1 alpha, IL-1 beta, and TNF-alpha from LPS-stimulated microglia, but had minimal effects on the release of IL-2, IL-4, IL-6, IL-10, MCP-1, and TGF-alpha.
Regulation (effects) of Localization (release) of MCP-1 in microglia
3) Confidence 0.07 Published 2009 Journal Glia Section Abstract Doc Link 19115387 Disease Relevance 0 Pain Relevance 1.68

General Comments

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