INT157049

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.46
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
microglia 2
Il4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 11 100.00 Very High Very High Very High
ketamine 136 98.84 Very High Very High Very High
tetrodotoxin 7 97.04 Very High Very High Very High
Inflammation 53 96.16 Very High Very High Very High
sodium channel 8 84.76 Quite High
Nav1.9 1 84.12 Quite High
nav1.8 1 83.64 Quite High
Nav1.7 1 83.32 Quite High
nav1.3 1 83.00 Quite High
Nav1.2 1 82.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 58 96.16 Very High Very High Very High
Asthma 60 95.48 Very High Very High Very High
Adhesions 1 79.08 Quite High
Edema 4 74.56 Quite High
Disease 2 51.20 Quite High
Eosinophilia 2 35.92 Quite Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 2 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
g/kg significantly down-regulate Th2 cytokine IL-4 secretion in BALF, which suggest that ketamine treatment could alleviate IL-4-mediated responses, airway inflammation and AHR.
Regulation (regulate) of Localization (secretion) of IL-4 associated with asthma, inflammation, ketamine and cytokine
1) Confidence 0.25 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 1.46 Pain Relevance 0.66
Phenytoin attenuated by approximately 50% the release of IL-1 alpha, IL-1 beta, and TNF-alpha from LPS-stimulated microglia, but had minimal effects on the release of IL-2, IL-4, IL-6, IL-10, MCP-1, and TGF-alpha.
Regulation (effects) of Localization (release) of IL-4 in microglia
2) Confidence 0.06 Published 2009 Journal Glia Section Abstract Doc Link 19115387 Disease Relevance 0 Pain Relevance 1.67

General Comments

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