INT157064

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (CALCRL) endosome (CALCRL) endoplasmic reticulum (CALCRL)
plasma membrane (CALCRL) lysosome (CALCRL) signal transducer activity (CALCRL)
Anatomy Link Frequency
plasma 2
CALCRL (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 100.00 Very High Very High Very High
opioid receptor 7 99.72 Very High Very High Very High
Glutamate receptor 10 97.32 Very High Very High Very High
Neurotransmitter 9 95.44 Very High Very High Very High
Thalamus 2 93.20 High High
Pain 5 81.56 Quite High
Opioid 2 75.20 Quite High
Analgesic 1 53.28 Quite High
Glutamate 3 47.92 Quite Low
long-term potentiation 2 11.68 Low Low
Disease Link Frequency Relevance Heat
Nociception 1 96.40 Very High Very High Very High
Pain 3 81.56 Quite High
Disease 6 50.00 Quite Low
Autism 5 12.92 Low Low
Intellectual Impairment 6 12.48 Low Low
Epilepsy 7 11.68 Low Low
Neurological Disease 7 10.96 Low Low
Depression 2 9.60 Low Low
Adhesions 3 5.00 Very Low Very Low Very Low
Schizophrenia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several publications then showed that other neurotransmitter receptors, such as GABAA receptors (Bogdanov et al., 2006) and ionotropic glutamate receptors (Borgdorff and Choquet, 2002), are also mobile within the neuronal plasma membrane, providing a basis for dynamic activity-dependent regulation of postsynaptic receptor numbers.
Negative_regulation (numbers) of Regulation (regulation) of receptor in plasma associated with neurotransmitter and glutamate receptor
1) Confidence 0.02 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526001 Disease Relevance 0 Pain Relevance 0.33
We show that the main effect of the N40D micro-opioid receptor variant is a reduction of the agonist-induced receptor signaling efficacy.
Negative_regulation (reduction) of Regulation (efficacy) of receptor associated with agonist and opioid receptor
2) Confidence 0.02 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19116204 Disease Relevance 0.33 Pain Relevance 0.86

General Comments

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