INT157066

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Context Info
Confidence 0.22
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpb2) extracellular space (Cpb2) extracellular region (Cpb2)
Anatomy Link Frequency
brainstem 2
Cpb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 1 100.00 Very High Very High Very High
Raphe 1 99.40 Very High Very High Very High
withdrawal 9 98.70 Very High Very High Very High
Serotonin 2 86.84 High High
Dynorphin 1 80.52 Quite High
Nucleus accumbens 1 76.56 Quite High
Hippocampus 1 70.96 Quite High
amygdala 1 69.68 Quite High
Central grey 1 59.76 Quite High
depression 1 34.88 Quite Low
Disease Link Frequency Relevance Heat
Depression 6 88.84 High High
Syndrome 2 77.16 Quite High
Urological Neuroanatomy 1 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examined the effects of chronic, escalating doses of D-AMPH followed by 24 h of withdrawal on the expression of prodynorphin (PD) and c-fos mRNA in limbic regions of the brain, caudate putamen (CPu), and brainstem and SERT mRNA expression in the dorsal raphe nucleus (DRN).
Regulation (regions) of Gene_expression (expression) of CPu in brainstem associated with medulla, raphe and withdrawal
1) Confidence 0.22 Published 2009 Journal Synapse Section Abstract Doc Link 19116947 Disease Relevance 0.47 Pain Relevance 0.64

General Comments

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