INT157067

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Context Info
Confidence 0.22
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.29
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpb2) extracellular space (Cpb2) extracellular region (Cpb2)
Anatomy Link Frequency
CPu 2
brainstem 2
Cpb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 9 100.00 Very High Very High Very High
Pain 7 100.00 Very High Very High Very High
antagonist 1 100.00 Very High Very High Very High
medulla 1 99.72 Very High Very High Very High
Raphe 1 97.76 Very High Very High Very High
tail-flick 1 94.00 High High
Sciatic nerve 1 92.24 High High
Serotonin 2 90.64 High High
Dynorphin 1 84.32 Quite High
Central nervous system 1 83.08 Quite High
Disease Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
Depression 6 92.64 High High
Nociception 4 87.84 High High
Syndrome 2 80.96 Quite High
Urological Neuroanatomy 1 56.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examined the effects of chronic, escalating doses of D-AMPH followed by 24 h of withdrawal on the expression of prodynorphin (PD) and c-fos mRNA in limbic regions of the brain, caudate putamen (CPu), and brainstem and SERT mRNA expression in the dorsal raphe nucleus (DRN).
Regulation (followed) of Regulation (regions) of CPu in brainstem associated with medulla, raphe and withdrawal
1) Confidence 0.22 Published 2009 Journal Synapse Section Abstract Doc Link 19116947 Disease Relevance 0.48 Pain Relevance 0.64
The present study examined the effects of NE and the alpha-adrenoceptor antagonist phentolamine on the pain-evoked response of pain-excitation neurons (PENs) and pain-inhibition neurons (PINs) in the CPu of rats.
Spec (examined) Regulation (effects) of Spec (examined) Regulation (response) of CPu in CPu associated with pain and antagonist
2) Confidence 0.22 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20553996 Disease Relevance 0.80 Pain Relevance 0.75

General Comments

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