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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.48
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PKLR) small molecule metabolic process (PKLR) carbohydrate metabolic process (PKLR)
Anatomy Link Frequency
reticulum 1
PKLR (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 3 100.00 Very High Very High Very High
cINOD 6 95.12 Very High Very High Very High
Inflammation 16 86.00 High High
sodium channel 2 84.32 Quite High
ischemia 22 64.24 Quite High
Action potential 1 60.40 Quite High
metalloproteinase 2 59.28 Quite High
bradykinin 3 47.08 Quite Low
Opioid 5 46.48 Quite Low
cocaine 1 38.40 Quite Low
Disease Link Frequency Relevance Heat
Stress 11 99.52 Very High Very High Very High
Heart Arrhythmia 3 99.14 Very High Very High Very High
Infection 120 98.78 Very High Very High Very High
Epstein-barr Virus 44 98.44 Very High Very High Very High
Apoptosis 99 98.36 Very High Very High Very High
Arrhythmias 2 Under Development 1 97.84 Very High Very High Very High
Cancer 246 97.16 Very High Very High Very High
Myocardial Infarction 12 96.16 Very High Very High Very High
Cold Sores 367 90.04 High High
INFLAMMATION 20 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac sulfide, the active sulindac metabolite, was shown to trigger the ISRs via eIF2alpha kinase such as RNA-dependent protein kinase-related endoplasmic reticulum kinase (PERK) and RNA-dependent protein kinase (PKR).
Positive_regulation (trigger) of PKR in reticulum
1) Confidence 0.36 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20130018 Disease Relevance 1.27 Pain Relevance 0.47
EBV latent infection induced the suppression of p38-MAPK activities, but did not activate PKR cascade.
Neg (not) Positive_regulation (activate) of PKR associated with epstein-barr virus and infection
2) Confidence 0.36 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.86 Pain Relevance 0.03
The Brugada syndrome is usually identified by a characteristic Brugada-type ECG that consists of ST elevation of a coved type in the precordial leads V1 to V3 and ventricular fibrillation that can lead to sudden cardiac death, although affected individuals may have a normal ECG.
Positive_regulation (elevation) of Brugada-type ECG associated with heart arrhythmia, arrhythmias 2 under development and myocardial infarction
3) Confidence 0.22 Published 2010 Journal Int. J. Cardiol. Section Abstract Doc Link 19117622 Disease Relevance 0.44 Pain Relevance 0.07
This effect is mediated through the cellular PKR kinase, which phosphorylates the translation initiation factor eIF2?
Positive_regulation (mediated) of PKR
4) Confidence 0.07 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.57 Pain Relevance 0
Interferon-alpha has two major routes of action: the direct antiviral effect of interferon-alpha is partly exerted by activation of double-stranded RNA-activated protein kinase (PKR) and with induction of the antiviral 2?
Positive_regulation (activation) of PKR
5) Confidence 0.03 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676642 Disease Relevance 0.17 Pain Relevance 0
Other studies have implicated that preconditioning reduces myocardial apoptosis through altering the balance between anti-apoptotic and pro-apoptotic proteins, the release of cytochrome c from mitochondria, caspase activation, and activation of protein kinase C isozymes.
Positive_regulation (activation) of isozymes associated with kinase c and apoptosis
6) Confidence 0.01 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 1.18 Pain Relevance 0.12

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