INT157095

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.60
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ddc) intracellular (Ddc) cellular amino acid metabolic process (Ddc)
cytoplasm (Ddc)
Anatomy Link Frequency
striatum 2
Plasma 1
neurons 1
Ddc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 156 99.28 Very High Very High Very High
dorsal root ganglion 84 98.92 Very High Very High Very High
chemokine 104 98.80 Very High Very High Very High
dopamine receptor 7 98.32 Very High Very High Very High
antagonist 41 86.96 High High
imagery 12 86.08 High High
isoflurane 5 81.88 Quite High
Pain 15 81.68 Quite High
anesthesia 3 81.40 Quite High
qutenza 14 56.88 Quite High
Disease Link Frequency Relevance Heat
Injury 68 99.96 Very High Very High Very High
Disease 95 99.88 Very High Very High Very High
Dyskinesias 113 99.64 Very High Very High Very High
Ganglion Cysts 84 98.92 Very High Very High Very High
Decapitation 1 95.92 Very High Very High Very High
Neuropathic Pain 32 86.44 High High
Parkinson's Disease 22 85.20 High High
Congenital Anomalies 11 73.60 Quite High
Body Weight 2 70.48 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 42 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sensitization to L-DOPA correlates with ectopic expression of D3 dopamine receptors in the striatum, implicating D3 receptors in development of LID.
L-DOPA Binding (Sensitization) of in striatum associated with dopamine receptor and dyskinesias
1) Confidence 0.27 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19118628 Disease Relevance 0.95 Pain Relevance 0.13
In sharp contrast, following the combination of gp120/hCD4 and ddC injury paradigm, mRNA transcripts were upregulated by POD 21 in the DRG ipsilateral to injury in virtually all neurons (Fig. 6E).


ddC Binding (combination) of in neurons associated with dorsal root ganglion and injury
2) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.19 Pain Relevance 0.52
Chemokines increase [Ca2+]i in DRG cells subjected to gp120/hCD4 treatment alone and in combination with ddC
ddC Binding (combination) of associated with dorsal root ganglion and chemokine
3) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.09 Pain Relevance 0.65
Plasma L-DOPA and its metabolites were measured using a method described previously [61] with minor modifications.
L-DOPA Binding (metabolites) of in Plasma
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916818 Disease Relevance 0.17 Pain Relevance 0.12
To determine whether these changes in striatal preproTRH mRNA in the L-DOPA-treated animals were accompanied by changes in the levels of TRH peptide, we performed RIAs and examined proTRH-like immunostaining of striatal tissues from the dopamine-depleted and control sides of rats treated with L-DOPA.
L-DOPA Spec (examined) Binding (treated) of associated with dopamine
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.30 Pain Relevance 0.12
Quantitative real-time polymerase chain reaction (PCR) was employed to evaluate the molecular changes associated with L-DOPA-induced dyskinesias in Parkinson's disease.
L-DOPA Binding (associated) of associated with disease and dyskinesias
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2978093 Disease Relevance 0.82 Pain Relevance 0.24
The levels of preproTRH mRNA were significantly increased in the dopamine-depleted striatum of the rats that developed dyskinesia in response to the L-DOPA treatment (mixed design analysis of variance [ANOVA]; Treatment × Side interaction: F1,31?
L-DOPA Binding (interaction) of in striatum associated with dopamine and dyskinesias
7) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.10 Pain Relevance 0.22

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