INT157104

Context Info Confidence 0.66 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 8 Disease Relevance 1.66 Pain Relevance 0.52

signal transduction (SOX9) nucleolus (SOX9) nucleus (SOX9) extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9)

Anatomy Link Frequency chondrocytes 1 SOX9 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 155 99.60 metalloproteinase 16 86.72 cINOD 2 69.44 Arthritis 7 64.08 Inflammation 97 44.48 rheumatoid arthritis 48 5.00 cytokine 33 5.00 Pain 10 5.00 Bioavailability 5 5.00 dexamethasone 4 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 169 99.60 Stress 21 86.04 Apoptosis 113 85.28 Hypertrophy 2 84.16 INFLAMMATION 94 68.88 Arthritis 14 64.08 Osteoporosis 2 30.24 Obesity 21 21.08 Rheumatoid Arthritis 48 5.00 Cancer 15 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Physiological tonicity also significantly increased AGC1 (Figure 3a) and SOX9 (Figure 3b) mRNA levels in nonosteoarthritic human articular chondrocytes (NHACs).

Positive_regulation (increased) of SOX9 in chondrocytes

1) Confidence 0.66 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.14 Pain Relevance 0.07

Interestingly, Tew and colleagues showed very recently that the mRNA of SOX9, an important regulator of COL2 expression, is stabilized by supraphysiological tonicity [70].

Positive_regulation (stabilized) of SOX9

2) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.14 Pain Relevance 0

The results demonstrated: (a) that expression levels of the catabolic genes MMP-3 and MMP-13 were suppressed and (b) mRNA expression levels of anabolic genes of collagen II, SOX9 and aggrecan were increased.

Positive_regulation (increased) of SOX9

3) Confidence 0.42 Published 2009 Journal Phytochemistry Section Abstract Doc Link 19118849 Disease Relevance 0.26 Pain Relevance 0.32

Physiological tonicity (380 mOsm) during isolation and subsequent passaging of OA HACs significantly increased mRNA levels of both AGC1 (Figure 2a) and SOX9 (Figure 2b) at all passages.

Positive_regulation (increased) of SOX9 associated with osteoarthritis

4) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.25 Pain Relevance 0.13

The aforementioned findings were consistent with the real-time PCR results, which showed the corresponding upregulation of SOX-9, aggrecan and type II collagen gene expression but downregulation of type I collagen expression by MPCs cultured in the presence of PPS.

Positive_regulation (upregulation) of SOX-9

5) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.08 Pain Relevance 0

1-integrin and activation of Shc, ERK 1/2 and Sox-9.

Positive_regulation (activation) of Sox-9

6) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.31 Pain Relevance 0

1-integrin, Shc, activated ERK 1/2 and Sox-9.

Positive_regulation (activated) of Sox-9

7) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.13 Pain Relevance 0

1-integrin, Shc, activated ERK 1/2 and Sox-9 (Figure 3C).

Positive_regulation (activated) of Sox-9

8) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.36 Pain Relevance 0

General Comments

This test has worked.