INT157104

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Context Info
Confidence 0.66
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 1.66
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SOX9) nucleolus (SOX9) nucleus (SOX9)
extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9)
Anatomy Link Frequency
chondrocytes 1
SOX9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 155 99.60 Very High Very High Very High
metalloproteinase 16 86.72 High High
cINOD 2 69.44 Quite High
Arthritis 7 64.08 Quite High
Inflammation 97 44.48 Quite Low
rheumatoid arthritis 48 5.00 Very Low Very Low Very Low
cytokine 33 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 169 99.60 Very High Very High Very High
Stress 21 86.04 High High
Apoptosis 113 85.28 High High
Hypertrophy 2 84.16 Quite High
INFLAMMATION 94 68.88 Quite High
Arthritis 14 64.08 Quite High
Osteoporosis 2 30.24 Quite Low
Obesity 21 21.08 Low Low
Rheumatoid Arthritis 48 5.00 Very Low Very Low Very Low
Cancer 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Physiological tonicity also significantly increased AGC1 (Figure 3a) and SOX9 (Figure 3b) mRNA levels in nonosteoarthritic human articular chondrocytes (NHACs).
Positive_regulation (increased) of SOX9 in chondrocytes
1) Confidence 0.66 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.14 Pain Relevance 0.07
Interestingly, Tew and colleagues showed very recently that the mRNA of SOX9, an important regulator of COL2 expression, is stabilized by supraphysiological tonicity [70].
Positive_regulation (stabilized) of SOX9
2) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.14 Pain Relevance 0
The results demonstrated: (a) that expression levels of the catabolic genes MMP-3 and MMP-13 were suppressed and (b) mRNA expression levels of anabolic genes of collagen II, SOX9 and aggrecan were increased.
Positive_regulation (increased) of SOX9
3) Confidence 0.42 Published 2009 Journal Phytochemistry Section Abstract Doc Link 19118849 Disease Relevance 0.26 Pain Relevance 0.32
Physiological tonicity (380 mOsm) during isolation and subsequent passaging of OA HACs significantly increased mRNA levels of both AGC1 (Figure 2a) and SOX9 (Figure 2b) at all passages.
Positive_regulation (increased) of SOX9 associated with osteoarthritis
4) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.25 Pain Relevance 0.13
The aforementioned findings were consistent with the real-time PCR results, which showed the corresponding upregulation of SOX-9, aggrecan and type II collagen gene expression but downregulation of type I collagen expression by MPCs cultured in the presence of PPS.
Positive_regulation (upregulation) of SOX-9
5) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.08 Pain Relevance 0
1-integrin and activation of Shc, ERK 1/2 and Sox-9.
Positive_regulation (activation) of Sox-9
6) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.31 Pain Relevance 0
1-integrin, Shc, activated ERK 1/2 and Sox-9.
Positive_regulation (activated) of Sox-9
7) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.13 Pain Relevance 0
1-integrin, Shc, activated ERK 1/2 and Sox-9 (Figure 3C).
Positive_regulation (activated) of Sox-9
8) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.36 Pain Relevance 0

General Comments

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