INT157105

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.88
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SOX9) nucleolus (SOX9) nucleus (SOX9)
extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9)
SOX9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 81 99.60 Very High Very High Very High
metalloproteinase 5 88.80 High High
cINOD 2 71.52 Quite High
Arthritis 3 66.16 Quite High
Inflammation 32 57.04 Quite High
rheumatoid arthritis 16 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 89 99.60 Very High Very High Very High
INFLAMMATION 32 70.96 Quite High
Apoptosis 34 67.68 Quite High
Arthritis 5 66.16 Quite High
Death 3 23.24 Low Low
Rheumatoid Arthritis 16 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Physiological tonicity (380 mOsm) during isolation and subsequent passaging of OA HACs significantly increased mRNA levels of both AGC1 (Figure 2a) and SOX9 (Figure 2b) at all passages.
Positive_regulation (increased) of Transcription (levels) of SOX9 associated with osteoarthritis
1) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.25 Pain Relevance 0.13
To demonstrate that the hypertonicity-induced chondrogenic marker expression was indeed mediated by NFAT5, we used RNAi to confirm that knockdown of NFAT5 significantly inhibited hypertonic induction of its own transcription as discussed before, significantly suppressed the tonicity-mediated induction of known NFAT5 targets, and, most importantly, significantly eliminated the hypertonicity-mediated mRNA expression of chondrogenic marker genes (COL2, AGC1, SOX9 and COL1).


Positive_regulation (mediated) of Transcription (expression) of SOX9
2) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.06 Pain Relevance 0.03
The results demonstrated: (a) that expression levels of the catabolic genes MMP-3 and MMP-13 were suppressed and (b) mRNA expression levels of anabolic genes of collagen II, SOX9 and aggrecan were increased.
Positive_regulation (increased) of Transcription (expression) of SOX9
3) Confidence 0.42 Published 2009 Journal Phytochemistry Section Abstract Doc Link 19118849 Disease Relevance 0.27 Pain Relevance 0.33
1-integrin was upregulated and Shc, activated ERK 1/2 and the chondrogenic specific transcription factor Sox-9 was highly expressed in MSC cultures treated with IL-1?
Positive_regulation (factor) of Transcription (transcription) of Sox-9
4) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.30 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox