INT157121

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 7.21
Pain Relevance 5.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GAD2) lyase activity (GAD2) Golgi apparatus (GAD2)
cytoplasmic membrane-bounded vesicle (GAD2) plasma membrane (GAD2) cytoplasm (GAD2)
Anatomy Link Frequency
sciatic nerve 2
spinal cord 2
synapse 2
primary visual cortex 1
GAD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 391 100.00 Very High Very High Very High
Pain 8 99.76 Very High Very High Very High
Sciatic nerve 20 99.62 Very High Very High Very High
Nicotine 9 99.60 Very High Very High Very High
Spinal cord 8 99.38 Very High Very High Very High
Cannabinoid receptor 126 99.14 Very High Very High Very High
GABAergic 667 99.12 Very High Very High Very High
Neuropathic pain 8 99.04 Very High Very High Very High
peripheral neuropathy 4 99.00 Very High Very High Very High
neuralgia 8 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 16 100.00 Very High Very High Very High
Pain 8 99.76 Very High Very High Very High
Diabetes Mellitus 22 99.62 Very High Very High Very High
Lifespan 243 99.28 Very High Very High Very High
Neuropathic Pain 8 99.04 Very High Very High Very High
Peripheral Neuropathy 4 99.00 Very High Very High Very High
Adenocarcinoma 1 98.72 Very High Very High Very High
Aging 153 97.00 Very High Very High Very High
Acanthosis 1 94.72 High High
Ketosis 1 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the peak of GAD65 expression was not reached until the teen to young adult years before falling off in aging.
Gene_expression (expression) of GAD65 associated with aging
1) Confidence 0.67 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.40 Pain Relevance 0.21
In the second stage, the teenage transition was a switch from a greater capacity for trafficking GABA (more VGAT) to a greater capacity to produce the on-demand pool of GABA (more GAD65).
Gene_expression (produce) of GAD65 associated with gaba
2) Confidence 0.67 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.06 Pain Relevance 0.17
In addition, because the development of GAD65 expression may extend into the young adult years it is possible that this affects plasticity in primary visual cortex and contributes to visual recovery promoted by perceptual learning treatment in adults with amblyopia (Levi and Li, 2009).
Gene_expression (expression) of GAD65 in primary visual cortex associated with amblyopia
3) Confidence 0.67 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.50 Pain Relevance 0.10
In the third stage, during the transition to older adults, there were two switches in the balance between components of the GABAergic signaling system: from greater capacity to produce GABA (more GAD65) to greater capacity to traffic GABA to the synapse (more VGAT); and from relatively more post-synaptic (more Gephyrin) to more pre-synaptic (more GAD65) expression.
Gene_expression (expression) of GAD65 in synapse associated with gaba and gabaergic
4) Confidence 0.58 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.28 Pain Relevance 0.36
It seems likely that the high levels of GAD65 and GABAA?
Gene_expression (levels) of GAD65
5) Confidence 0.58 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0 Pain Relevance 0.30
In the third stage, during the transition to older adults, there were two switches in the balance between components of the GABAergic signaling system: from greater capacity to produce GABA (more GAD65) to greater capacity to traffic GABA to the synapse (more VGAT); and from relatively more post-synaptic (more Gephyrin) to more pre-synaptic (more GAD65) expression.
Gene_expression (produce) of GAD65 in synapse associated with gaba and gabaergic
6) Confidence 0.52 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.19 Pain Relevance 0.36
We quantified the inhibitory modulating cannabinoid receptor (CB1), GABA vesicular transporter (VGAT), GABA synthesizing enzymes (GAD65/GAD67), GABAA receptor anchoring protein (Gephyrin), and GABAA receptor subunits (GABAA?
Gene_expression (synthesizing) of GAD65 associated with gaba and cannabinoid receptor
7) Confidence 0.52 Published 2010 Journal Frontiers in Cellular Neuroscience Section Abstract Doc Link PMC2893712 Disease Relevance 0.35 Pain Relevance 0.39
To determine the relative contribution of pre- versus post-synaptic components of GABAergic signaling across the lifespan, we calculated a index of Gephyrin:GAD65 expression (Figure 6).
Gene_expression (expression) of GAD65 associated with lifespan and gabaergic
8) Confidence 0.52 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.34 Pain Relevance 0.11
There were no significant correlations (p values >0.1) between postmortem interval and the expression level for any of the antibodies (GAD65, R =?
Gene_expression (expression) of GAD65
9) Confidence 0.51 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.13 Pain Relevance 0.31
In contrast to this observation, nicotine suppresses protein levels of GAD isozymes (mainly GAD65) and GABA in pancreatic ductal adenocarcinoma tissue [35].
Gene_expression (levels) of GAD65 associated with adenocarcinoma, gaba, generalized anxiety disorder and nicotine
10) Confidence 0.31 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.88 Pain Relevance 0.28
Recently, we demonstrated that the administration of GAD65-expressing rAAV2 to DRG attenuates peripheral neuropathy by inducing GABA release in the spinal cord.
Gene_expression (expressing) of GAD65 in spinal cord associated with gaba, peripheral neuropathy and spinal cord
11) Confidence 0.23 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19643087 Disease Relevance 0.40 Pain Relevance 0.52
Both GFP and GAD65 expression indicated that effective transgene delivery to the DRG can be accomplished via sciatic nerve administration.
Gene_expression (expression) of GAD65 in sciatic nerve associated with sciatic nerve
12) Confidence 0.23 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19643087 Disease Relevance 0.52 Pain Relevance 0.83
Equally importantly, the GABA concentration in the spinal cord increased significantly after GAD65 introduction, and pain symptoms were dramatically reduced and persistently controlled.
Gene_expression (introduction) of GAD65 in spinal cord associated with pain, gaba and spinal cord
13) Confidence 0.20 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19643087 Disease Relevance 0.50 Pain Relevance 0.82
Effective neuropathic pain relief through sciatic nerve administration of GAD65-expressing rAAV2.
Gene_expression (expressing) of GAD65 in sciatic nerve associated with neuralgia, neuropathic pain and sciatic nerve
14) Confidence 0.18 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 19643087 Disease Relevance 0.51 Pain Relevance 0.98
When compared with that of T2D, a higher proportion of patients with T1D were positive for GAD-65 and IA-2 antibodies, and this difference was statistically significant for GAD-65 antibodies.
Gene_expression (antibodies) of GAD-65 associated with generalized anxiety disorder and diabetes mellitus
15) Confidence 0.09 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 19120303 Disease Relevance 2.16 Pain Relevance 0.17

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