INT157135

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.51
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MKI67) nucleolus (MKI67) nucleus (MKI67)
intracellular (MKI67) cell cycle (MKI67) DNA metabolic process (MKI67)
Anatomy Link Frequency
T cell 1
MKI67 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 85.68 High High
cva 7 83.52 Quite High
fibrosis 4 80.56 Quite High
anesthesia 2 64.08 Quite High
abdominal pain 1 51.44 Quite High
headache 8 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Shingles 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 56 99.52 Very High Very High Very High
Malignant Neoplastic Disease 12 99.20 Very High Very High Very High
Carcinoma 7 98.92 Very High Very High Very High
Cancer 314 98.72 Very High Very High Very High
Nicotine Addiction 44 98.64 Very High Very High Very High
Breast Cancer 102 97.96 Very High Very High Very High
Disease 44 96.08 Very High Very High Very High
Ganglion Cysts 36 94.28 High High
Lung Cancer 76 91.84 High High
Oligodendroglioma 57 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Shabaan and coworkers [4], in a cross-sectional study, observed that women with increased Ki-67 in foci of hyperplasia were at increased risk for breast cancer.
Positive_regulation (increased) of Ki-67 associated with breast cancer and hyperplasia
1) Confidence 0.60 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.76 Pain Relevance 0
At least two slides were Papanicolaou stained, with one used for morphology and one for Ki-67 staining.
Positive_regulation (one) of Ki-67
2) Confidence 0.44 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.35 Pain Relevance 0.06
The tumor cells were negative for p53 protein, but the malignant foci were positive for p53 protein and had high Ki-67 antigen (labeling 60%).
Positive_regulation (had) of Ki-67 associated with malignant neoplastic disease and cancer
3) Confidence 0.11 Published 2009 Journal Pathol. Int. Section Abstract Doc Link 19121093 Disease Relevance 0.88 Pain Relevance 0.05
Double immunostaining was planned later because of increased Ki67 staining observed in the control biopsy after RFITT.
Positive_regulation (increased) of Ki67
4) Confidence 0.07 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2535598 Disease Relevance 0.52 Pain Relevance 0.04
Field cancerization is also demonstrated by the elevated Ki-67 labeling index in the airways of smokers at more than one site [67].
Positive_regulation (elevated) of Ki-67 associated with nicotine addiction
5) Confidence 0.05 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 1.47 Pain Relevance 0
The carcinoma cells in all cases (14 cases) of PIDC were diffusely positive for MUC1, 45M1, p53 and Ki67, and focally positive for MUC6.
Positive_regulation (positive) of Ki67 associated with carcinoma
6) Confidence 0.05 Published 2005 Journal J Carcinog Section Body Doc Link PMC1185555 Disease Relevance 1.05 Pain Relevance 0.08
Fig. 3A box plot of before and after treatment Ki67 values in the estrogen-receptor-positive, human epidermal growth factor receptor (HER) 1/2+ subset.
Positive_regulation (after) of Ki67
7) Confidence 0.03 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.80 Pain Relevance 0
The Ki-67 labeling index was markedly elevated in the oligodendroglial portions, reaching up to 44% (Fig. 3g).
Positive_regulation (elevated) of Ki-67
8) Confidence 0.02 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2892612 Disease Relevance 0.99 Pain Relevance 0.04
Baseline aromatase expression did not predict response to letrozole or tamoxifen, or changes in Ki67 induced by treatment.
Positive_regulation (induced) of Ki67
9) Confidence 0.02 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.63 Pain Relevance 0
T cell proliferation in PBMCs (Figure 4) and BAL (Figure 5) was also determined by measuring the relative (fold) increase in the number (PBMC) or percentage (BAL) of Ki67+.
Positive_regulation (increase) of Ki67 in T cell
10) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2770849 Disease Relevance 0.07 Pain Relevance 0

General Comments

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