INT157142

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.30
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (OPA1) plasma membrane (Camk2a) mitochondrion organization (OPA1)
GTPase activity (OPA1) kinase activity (Camk2a)
Anatomy Link Frequency
TNC 2
OPA1 (Homo sapiens)
Camk2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 4 99.68 Very High Very High Very High
Migraine 8 94.56 High High
headache 4 87.92 High High
COX2 8 25.00 Low Low
cOX1 8 25.00 Low Low
Disease Link Frequency Relevance Heat
Headache 12 80.12 Quite High
Cluster Headache 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our experiments, we demonstrated that pretreatment with NS398, the selective COX-2 inhibitor attenuated the NTG-induced CamKIIalpha expression in the TNC at doses of 3 and 5mg/kg.
NTG Positive_regulation (induced) of Gene_expression (expression) of CamKIIalpha in TNC associated with cox-2 inhibitor
1) Confidence 0.02 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19121366 Disease Relevance 0.07 Pain Relevance 0.26
The aim of our study was to determine if any isoforms of the cyclooxygenase (COX) enzyme might have a role in the NTG-induced increase of CamKIIalpha expression.
NTG Positive_regulation (increase) of Gene_expression (expression) of CamKIIalpha
2) Confidence 0.02 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19121366 Disease Relevance 0.08 Pain Relevance 0.24
These findings suggest that COX-2, but not COX-1 derived metabolites are important factors in the NTG-induced CamKIIalpha expression.
NTG Positive_regulation (induced) of Gene_expression (expression) of CamKIIalpha
3) Confidence 0.02 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19121366 Disease Relevance 0.06 Pain Relevance 0.29
The aim of our study was to determine if any isoforms of the cyclooxygenase (COX) enzyme might have a role in the NTG-induced increase of CamKIIalpha expression.
NTG Positive_regulation (induced) of Gene_expression (expression) of CamKIIalpha
4) Confidence 0.02 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19121366 Disease Relevance 0.08 Pain Relevance 0.24

General Comments

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