INT157151

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (LSS, CPOX) mitochondrion (CPOX) oxidoreductase activity (CPOX)
endoplasmic reticulum (LSS) cytoplasm (CPOX)
Anatomy Link Frequency
endothelial cells 1
LSS (Homo sapiens)
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1 95.84 Very High Very High Very High
aspirin 3 25.00 Low Low
Inflammation 3 25.00 Low Low
cINOD 2 25.00 Low Low
COX2 1 25.00 Low Low
agonist 1 25.00 Low Low
cOX1 1 25.00 Low Low
antagonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 8 100.00 Very High Very High Very High
Cancer 2 98.36 Very High Very High Very High
Necrosis 2 98.12 Very High Very High Very High
Atherosclerosis 2 97.80 Very High Very High Very High
INFLAMMATION 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have addressed whether the induction of COX-2-dependent prostanoids in endothelial cells by LSS plays a role in restraining endothelial tumor necrosis factor (TNF)-alpha generation, a proatherogenic cytokine, through the induction of heme oxygenase-1 (HO)-1, an antioxidant enzyme.
LSS Spec (whether) Positive_regulation (induction) of COX in endothelial cells associated with stress, necrosis, cancer and cytokine
1) Confidence 0.17 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19122175 Disease Relevance 0.89 Pain Relevance 0.05

General Comments

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