INT157219

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.50
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (WNK1)
Anatomy Link Frequency
phagocytes 2
WNK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Peripheral nervous system 9 93.04 High High
Hsan 2 88.60 High High
bDMF 21 70.36 Quite High
tolerance 4 13.12 Low Low
Central nervous system 60 5.00 Very Low Very Low Very Low
Neuropeptide 45 5.00 Very Low Very Low Very Low
projection neuron 40 5.00 Very Low Very Low Very Low
GABA receptor 32 5.00 Very Low Very Low Very Low
Glutamate 32 5.00 Very Low Very Low Very Low
gABA 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hereditary Sensory And Autonomic Neuropathies 8 100.00 Very High Very High Very High
Aging 11 99.26 Very High Very High Very High
Disease 238 99.12 Very High Very High Very High
Shock 32 95.68 Very High Very High Very High
Neurodegenerative Disease 7 91.72 High High
Sprains And Strains 174 77.12 Quite High
Cardiovascular Disease 33 68.24 Quite High
Stress 53 45.68 Quite Low
Infection 151 38.36 Quite Low
Death 41 30.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the 48 genes that overlapped between 558 AD-ageing common genes and genes in module 1, WNK1 and MAP4 were present.
Gene_expression (present) of WNK1 associated with aging and disease
1) Confidence 0.58 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 1.21 Pain Relevance 0.07
Four missense mutations (C133W, C133Y, V144D and G387A) in SPTLC1 were reported to cause HSAN I.
Gene_expression (cause) of HSAN I associated with hereditary sensory and autonomic neuropathies
2) Confidence 0.14 Published 2009 Journal Neurogenetics Section Abstract Doc Link 19132419 Disease Relevance 0.67 Pain Relevance 0.21
C: 5.13 (Hsn-2)/172.4, 172.6 (COO); 4.34 and 4.13 (Hsn-1)/172.4, 172.6 (COO); 2.28 (?
Gene_expression (/) of Hsn-2
3) Confidence 0.07 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866487 Disease Relevance 0 Pain Relevance 0
We confirmed this hypothesis by showing that whereas E. coli kdp genes are not expressed after phagocytosis, the kdp genes of Photorhabdus are strongly expressed within Manduca phagocytes.


Gene_expression (expressed) of kdp in phagocytes
4) Confidence 0.03 Published 2006 Journal Journal of Insect Science Section Body Doc Link PMC2990333 Disease Relevance 0.16 Pain Relevance 0
We confirmed this hypothesis by showing that whereas E. coli kdp genes are not expressed after phagocytosis, the kdp genes of Photorhabdus are strongly expressed within Manduca phagocytes.


Neg (not) Gene_expression (expressed) of kdp in phagocytes
5) Confidence 0.03 Published 2006 Journal Journal of Insect Science Section Body Doc Link PMC2990333 Disease Relevance 0.16 Pain Relevance 0
Since expression of the two-component regulator genes alone is sufficient for persistence, we conjectured that the distinctive feature of Photorhabdus kdp is the sensor-regulator pair, which can also regulate expression of the E. coli kdp genes to the detriment of the host insect.
Gene_expression (expression) of kdp
6) Confidence 0.03 Published 2006 Journal Journal of Insect Science Section Body Doc Link PMC2990333 Disease Relevance 0.15 Pain Relevance 0
Since expression of the two-component regulator genes alone is sufficient for persistence, we conjectured that the distinctive feature of Photorhabdus kdp is the sensor-regulator pair, which can also regulate expression of the E. coli kdp genes to the detriment of the host insect.
Gene_expression (expression) of kdp
7) Confidence 0.03 Published 2006 Journal Journal of Insect Science Section Body Doc Link PMC2990333 Disease Relevance 0.15 Pain Relevance 0

General Comments

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