INT157226

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.21
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
extracellular matrix 2
Tnnc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 95 99.44 Very High Very High Very High
Inflammatory response 19 97.52 Very High Very High Very High
Angina 11 95.56 Very High Very High Very High
ischemia 60 93.60 High High
cva 24 84.32 Quite High
cytokine 17 71.40 Quite High
Opioid 6 7.96 Low Low
isoflurane 13 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
methadone 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pyometra 204 99.90 Very High Very High Very High
Necrosis 4 99.56 Very High Very High Very High
INFLAMMATION 101 99.44 Very High Very High Very High
Cv General 2 Under Development 5 98.36 Very High Very High Very High
Systemic Inflammatory Response Syndrome 204 98.12 Very High Very High Very High
Hypertension 6 97.92 Very High Very High Very High
Death 30 96.92 Very High Very High Very High
Body Weight 12 96.16 Very High Very High Very High
Cv General 3 Under Development 3 95.56 Very High Very High Very High
Cv Unclassified Under Development 53 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two (13%) of the control dogs had increased cTnI concentrations the day after surgery (0.4 and 3 ?
Positive_regulation (increased) of Gene_expression (concentrations) of cTnI
1) Confidence 0.49 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.66 Pain Relevance 0
Thus, in total, 20 dogs (43%) with pyometra had increased cTnI concentrations before or after surgery, and 7 dogs had pre- or postoperative cTnI concentrations of 1.0 ?
Positive_regulation (increased) of Gene_expression (concentrations) of cTnI associated with pyometra
2) Confidence 0.49 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.53 Pain Relevance 0
Thirteen (28%) of the dogs had increased cTnI concentrations (> 0.2 ?
Positive_regulation (increased) of Gene_expression (concentrations) of cTnI
3) Confidence 0.49 Published 2008 Journal Acta Vet Scand Section Abstract Doc Link PMC2546406 Disease Relevance 1.01 Pain Relevance 0.17
Seven dogs (15%) had pre-or postoperative concentrations of cTnI of 1.0 ?
Positive_regulation (concentrations) of Gene_expression (concentrations) of cTnI
4) Confidence 0.43 Published 2008 Journal Acta Vet Scand Section Abstract Doc Link PMC2546406 Disease Relevance 0.49 Pain Relevance 0.03
Preoperative cTnI-concentrations
Positive_regulation (Preoperative) of Gene_expression (Preoperative) of cTnI
5) Confidence 0.43 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.65 Pain Relevance 0
Postoperative cTnI concentrations
Positive_regulation (Postoperative) of Gene_expression (concentrations) of cTnI
6) Confidence 0.43 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.67 Pain Relevance 0
Although increased cTnI or cTnT values always indicate myocardial tissue damage, a positive test is not able to identify the mechanism responsible for that cardiac damage (which could be not due to ischemia).
Positive_regulation (increased) of Gene_expression (values) of cTnI associated with ischemia
7) Confidence 0.43 Published 2009 Journal Adv Clin Chem Section Abstract Doc Link 19947353 Disease Relevance 0.82 Pain Relevance 0.14
There were 2 cases with acute blunt cardiac trauma and intracranial hemorrhage, respectively, that produced cTnI results that were initially low (<0.04 and 0.05 microg/l, respectively), but significantly increased with serial testing thereby producing false positive Delta cTnI results for AMI.
Positive_regulation (increased) of Gene_expression (producing) of cTnI
8) Confidence 0.27 Published 2009 Journal Clin. Chim. Acta Section Body Doc Link 19135041 Disease Relevance 0 Pain Relevance 0
cTnI: cardiac troponin I

Competing interests

Positive_regulation (interests) of Gene_expression (interests) of cTnI
9) Confidence 0.07 Published 2006 Journal J Cardiothorac Surg Section Body Doc Link PMC1524755 Disease Relevance 0.20 Pain Relevance 0.03
For example, proteins contributing to angiogenesis (VEGFR1), extracellular matrix remodeling (MMP-2 and MMP-3) were not upregulated in ischemic/reperfused muscles as compared to myotoxin injured muscles, whereas some factors regulating the activation and migration of leukocytes in injured tissues (MIP-1, MIP-2 and MIP-3) and inflammation (sTNF R1 and sTNF R2) were increased in ischemic/reperfused muscles (Table 1).
Positive_regulation (increased) of Gene_expression (reperfused) of muscles in extracellular matrix associated with inflammation
10) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2866363 Disease Relevance 0.24 Pain Relevance 0.15
In hemodynamically stable PE, BNP/cTnI measurement could be helpful on admission, especially for ruling out circulatory failure and in-hospital death.39

Pulmonary hypertension

Positive_regulation (helpful) of Gene_expression (measurement) of cTnI associated with cv general 2 under development, hypertension and death
11) Confidence 0.03 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824858 Disease Relevance 0.93 Pain Relevance 0.04

General Comments

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