INT15723

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 47
Total Number 52
Disease Relevance 37.59
Pain Relevance 8.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fn1) extracellular region (Fn1) cell adhesion (Fn1)
proteinaceous extracellular matrix (Fn1) extracellular matrix organization (Fn1)
Anatomy Link Frequency
extracellular matrix 5
blood 4
epithelial cells 3
plasma 2
retina 2
Fn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 202 100.00 Very High Very High Very High
intrathecal 13 100.00 Very High Very High Very High
cINOD 10 99.60 Very High Very High Very High
chemokine 18 99.38 Very High Very High Very High
cytokine 77 99.18 Very High Very High Very High
metalloproteinase 12 98.96 Very High Very High Very High
Arthritis 109 98.40 Very High Very High Very High
Chronic pancreatitis 34 98.40 Very High Very High Very High
Inflammation 185 98.36 Very High Very High Very High
Peripheral nerve injury 5 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Fibrosis 234 100.00 Very High Very High Very High
Neutropenia 12 100.00 Very High Very High Very High
Diabetes Mellitus 1272 99.84 Very High Very High Very High
Retinal Diseases 39 99.78 Very High Very High Very High
Albuminuria 31 99.76 Very High Very High Very High
Hypertrophy 29 99.74 Very High Very High Very High
Hypertension 431 99.48 Very High Very High Very High
Diabetic Retinopathy 182 99.48 Very High Very High Very High
Injury 164 99.36 Very High Very High Very High
Renal Disease 92 99.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, old rats' hind leg muscle samples were analysed using fluorescent microscopy for the expression of fibronectin, which is an early marker of connective tissue formation.
Gene_expression (expression) of fibronectin in leg muscle
1) Confidence 0.78 Published 1997 Journal Neuroscience Section Abstract Doc Link 9200744 Disease Relevance 0 Pain Relevance 0.14
Fibronectin is a member of the extracellular matrix molecules and is actively produced in response to injury and diseases in the CNS.
Gene_expression (produced) of Fibronectin in extracellular matrix associated with injury and disease
2) Confidence 0.75 Published 2006 Journal Glia Section Abstract Doc Link 16534777 Disease Relevance 0.77 Pain Relevance 0.37
Our report shows that NSAID also fail to alter production of high levels of plasma Fn.
Gene_expression (production) of Fn in plasma associated with cinod
3) Confidence 0.68 Published 1985 Journal J. Rheumatol. Section Abstract Doc Link 4057197 Disease Relevance 0.84 Pain Relevance 0.47
Pathogens for FN were detected in three cases and they disappeared in one case.
Gene_expression (detected) of FN associated with neutropenia
4) Confidence 0.63 Published 2010 Journal J. Infect. Chemother. Section Abstract Doc Link 20130951 Disease Relevance 1.27 Pain Relevance 0.09
Substantial inversion by the duodenum was observed (serosal S:R ratio, 1.2) with maximal inversion by the jejunum (serosal S:R ratio, 2.2), whereas inversion of R-FN was absent in the stomach.
Neg (absent) Gene_expression (absent) of R-FN in stomach
5) Confidence 0.60 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1865366 Disease Relevance 0 Pain Relevance 0
The appearances of fibronectin, alpha 5 beta 1, vinculin and actin in regenerating epithelial cells and fibroblasts during tracheal wound healing are well coordinated.
Gene_expression (appearances) of fibronectin in epithelial cells associated with wound healing
6) Confidence 0.57 Published 1994 Journal Virchows Arch. Section Abstract Doc Link 7529621 Disease Relevance 0.51 Pain Relevance 0.06
During the initial cell migration phase, plasma fibronectin may stimulate cell migration before cellular fibronectin is produced in situ, and regenerating epithelial cells appear to begin to migrate into the wound before cell proliferation starts.
Gene_expression (produced) of fibronectin in epithelial cells associated with injury
7) Confidence 0.57 Published 1994 Journal Virchows Arch. Section Abstract Doc Link 7529621 Disease Relevance 0.46 Pain Relevance 0.05
Synchronous appearance of fibronectin, integrin alpha 5 beta 1, vinculin and actin in epithelial cells and fibroblasts during rat tracheal wound healing.
Gene_expression (appearance) of fibronectin in epithelial cells associated with wound healing
8) Confidence 0.57 Published 1994 Journal Virchows Arch. Section Title Doc Link 7529621 Disease Relevance 0.50 Pain Relevance 0.09
Pancreata were histopathologically examined at every 4 weeks, and the expression of fibrosis-related factors such as transforming growth factor beta1 (TGF-beta1), fibronectin (FN), alpha-smooth muscle actin (alpha-SMA), and type III collagen was analyzed.
Spec (analyzed) Gene_expression (expression) of FN in smooth muscle associated with fibrosis
9) Confidence 0.54 Published 2001 Journal Pancreas Section Abstract Doc Link 11138977 Disease Relevance 0.87 Pain Relevance 0.58
Pancreata were histopathologically examined at every 4 weeks, and the expression of fibrosis-related factors such as transforming growth factor beta1 (TGF-beta1), fibronectin (FN), alpha-smooth muscle actin (alpha-SMA), and type III collagen was analyzed.
Spec (analyzed) Gene_expression (expression) of fibronectin in smooth muscle associated with fibrosis
10) Confidence 0.54 Published 2001 Journal Pancreas Section Abstract Doc Link 11138977 Disease Relevance 0.87 Pain Relevance 0.58
However, in the TJ-10-treated rats, the rate of pancreatic fibrosis and the expression of TGF-beta1, FN, alpha-SMA, and type III collagen at 12 and 16 weeks decreased significantly compared to those in the untreated rats.
Gene_expression (expression) of FN associated with fibrosis
11) Confidence 0.54 Published 2001 Journal Pancreas Section Abstract Doc Link 11138977 Disease Relevance 0.80 Pain Relevance 0.55
An intrathecal synthesis of Fn was established in 24/76 patients, most often in inflammatory (9/15) processes but rarely (3/17) in MS.
Gene_expression (synthesis) of Fn associated with inflammation and intrathecal
12) Confidence 0.50 Published 1991 Journal J. Neurol. Sci. Section Abstract Doc Link 1757796 Disease Relevance 0.67 Pain Relevance 0.41
Fibronectin in plasma and CSF: evidence for its intrathecal synthesis.
Gene_expression (synthesis) of Fibronectin in plasma associated with intrathecal
13) Confidence 0.50 Published 1991 Journal J. Neurol. Sci. Section Title Doc Link 1757796 Disease Relevance 0.60 Pain Relevance 0.35
The enhanced expression of p27Kip1 and fibronectin reflected a generalized response to hyperglycemia in target organs such as the kidney.
Gene_expression (expression) of fibronectin in kidney associated with hyperglycemia
14) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.12 Pain Relevance 0
Western blot analysis of total retinal lysates revealed a significant increase in fibronectin expression in diabetic SHR compared with control SHR (p=0.04) or diabetic (p=0.03) and control WKY (p=0.009; Figure 5).
Gene_expression (expression) of fibronectin associated with diabetes mellitus
15) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.16 Pain Relevance 0
Fibronectin, a component of the basement membrane, is overexpressed in the retina of diabetic adults [15].
Gene_expression (overexpressed) of Fibronectin in retina associated with diabetes mellitus
16) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.62 Pain Relevance 0
To identify factors potentially involved in the pathogenesis of diabetic retinopathy, we examined the retinal expression of fibronectin, an extracellular matrix component associated with functional properties of the inner blood-retinal barrier.
Spec (examined) Gene_expression (expression) of fibronectin in blood associated with diabetic retinopathy
17) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.20 Pain Relevance 0
As revealed in the present study, retinal tissue from diabetic WKY rats and nondiabetic SHR showed enhanced fibronectin expression in total retinal lysates, although this expression was not significantly different from that in control WKY rats.
Gene_expression (expression) of fibronectin associated with diabetes mellitus
18) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.23 Pain Relevance 0
The accumulation of p27Kip1 in retinal tissue is accompanied by increased fibronectin expression in diabetic hypertensive rats.
Gene_expression (expression) of fibronectin associated with diabetes mellitus and hypertension
19) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.43 Pain Relevance 0
This is the first demonstration of an association between increased expression of p27Kip1 and fibronectin accumulation in retinal tissue, and could contribute to thickening of the retinal capillary basement membrane seen in diabetic retina.


Gene_expression (expression) of fibronectin in retina associated with diabetes mellitus
20) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.06 Pain Relevance 0

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