INT157237

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (CLOCK) DNA binding (CLOCK) cytoplasm (CLOCK)
signal transducer activity (CLOCK) signal transduction (CLOCK) chromosome (CLOCK)
Anatomy Link Frequency
plasma 1
CLOCK (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 3 48.24 Quite Low
Neuropeptide 4 46.96 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
Sciatic nerve 3 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
opiate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 1 88.68 High High
Sleep Disorders 3 54.24 Quite High
Stress 9 53.68 Quite High
Opiate Addiction 1 50.00 Quite Low
Cancer 3 46.52 Quite Low
Stroke 3 28.80 Quite Low
Coronary Artery Disease 3 28.32 Quite Low
Diabetes Mellitus 12 27.20 Quite Low
Obesity 6 26.12 Quite Low
Apoptosis 3 20.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Outcome measures were the relative expression of clock gene mRNA (hperiod1, hperiod2, hclock) and the levels of serum cortisol, plasma ACTH, beta-endorphin (beta-EP), leptin, neuropeptide Y, interleukin-2 (IL-2), and tumor necrosis factor (TNF) in these subjects.
Gene_expression (expression) of clock in plasma
1) Confidence 0.58 Published 2009 Journal Biol. Psychiatry Section Body Doc Link 19135652 Disease Relevance 0.09 Pain Relevance 0
Although most studies have focused on the rhythmic expression of these few core clock genes, recent evidence suggests that genes regulated in a circadian fashion (or circadian output genes) constitute 8-10% of all genes expressed in mouse tissues [19,20].
Gene_expression (expression) of clock
2) Confidence 0.41 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.05 Pain Relevance 0
However, the observed opposite regulation may reflect opposing phases of core clock gene expression between human and mouse peripheral tissues.
Gene_expression (expression) of clock
3) Confidence 0.41 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.05 Pain Relevance 0
Quantitative RT-PCR also provided a potential explanation for our inability to detect a significant change in the expression of the circadian-regulated core clock genes Cry1 and Bmal1 in hSkM [19,20], as these genes cycle out of phase with Per1 and Per2 in mSkM (Figure 3) and in many other tissues, including mLvr [19] and mHrt [19].
Gene_expression (expression) of clock
4) Confidence 0.32 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0

General Comments

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