INT157238

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.21
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PER1) protein binding transcription factor activity (PER1) cytoplasm (PER1)
signal transducer activity (PER1)
PER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 147 99.64 Very High Very High Very High
Dopamine 4 38.32 Quite Low
Serotonin 1 18.16 Low Low
Neuropeptide 2 16.88 Low Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
opiate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 1 75.44 Quite High
Sleep Disorders 1 68.72 Quite High
Newborn Drug Withdrawal Syndrome 4 63.56 Quite High
Opiate Addiction 1 50.00 Quite Low
Stroke 1 43.28 Quite Low
Coronary Artery Disease 1 42.80 Quite Low
Diabetes Mellitus 4 41.68 Quite Low
Obesity 2 40.60 Quite Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These proteins form heterodimers, bind to specific DNA regulatory elements (E-boxes), and initiate transcription of Per 1, 2, and 3 and Cry 1 and 2.
Transcription (transcription) of Per
1) Confidence 0.50 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.07 Pain Relevance 0
Following a single 15-min immersion in cocaine solution, cocaine levels in larvae corresponded to 0.4–0.6 ng per 100 µg protein and 9–12 ng per 100 µg protein for the 1.5 and 30 µM doses, respectively.
Transcription (corresponded) of per associated with cocaine
2) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899232 Disease Relevance 0.06 Pain Relevance 0.74
RESULTS: Compared with healthy volunteers, abstinent addicts showed disruptions in diurnal rhythms of hPER1 and hPER2 mRNA expression, along with disruptions in diurnal rhythms of cortisol, ACTH, beta-endorphin, leptin, and IL-2 release.
Transcription (expression) of hPER1
3) Confidence 0.01 Published 2009 Journal Biol. Psychiatry Section Body Doc Link 19135652 Disease Relevance 0.08 Pain Relevance 0

General Comments

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