INT15724

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Context Info
Confidence 0.53
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 5.61
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fn1) extracellular region (Fn1) cell adhesion (Fn1)
proteinaceous extracellular matrix (Fn1) extracellular matrix organization (Fn1)
Anatomy Link Frequency
plasma 4
granulocyte 2
MCL 1
blood 1
LFCN 1
Fn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 7 100.00 Very High Very High Very High
c fibre 5 99.70 Very High Very High Very High
anesthesia 18 98.72 Very High Very High Very High
aspirin 4 97.62 Very High Very High Very High
cINOD 11 97.38 Very High Very High Very High
fibrosis 61 96.96 Very High Very High Very High
methotrexate 7 96.84 Very High Very High Very High
qutenza 6 96.16 Very High Very High Very High
Inflammation 53 91.28 High High
isoflurane 2 79.20 Quite High
Disease Link Frequency Relevance Heat
Acute-phase Reaction 6 99.66 Very High Very High Very High
Fibrosis 70 99.50 Very High Very High Very High
Diabetes Mellitus 3 98.68 Very High Very High Very High
Sleep Disorders 2 98.48 Very High Very High Very High
Arthritis 8 93.80 High High
Injury 17 91.52 High High
INFLAMMATION 56 91.28 High High
Stress 21 90.76 High High
Ureteral Obstruction 29 88.80 High High
Disease 19 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of the acute phase response was measured by reduction of high plasma Fn levels (42-79% decrease) and CRP levels (57-100% decrease) as well as elevation of subnormal levels of plasma albumin (57-101% increase) and iron (40-114% increase).
Negative_regulation (reduction) of Fn in plasma associated with acute-phase reaction
1) Confidence 0.53 Published 1988 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 3143680 Disease Relevance 1.22 Pain Relevance 0.63
These results suggest that the EDA(+) FN was most efficiently reduced by cryofiltration, would become a good indicator on plasmapheresis, and might move from other tissues into the blood during cryofiltration.
Negative_regulation (reduced) of FN in blood
2) Confidence 0.52 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7896431 Disease Relevance 0.36 Pain Relevance 0.15
Whether the NSAID was aspirin (100 mg/kg), phenylbutazone (10, 30, or 100 mg/kg) or indomethacin (0.3, 1 or 3 mg/kg) the pattern remained the same--reduced paw volume and unchanged high plasma Fn levels.
Negative_regulation (reduced) of Fn in plasma associated with aspirin and cinod
3) Confidence 0.43 Published 1985 Journal J. Rheumatol. Section Abstract Doc Link 4057197 Disease Relevance 0.92 Pain Relevance 0.49
Substantial inversion by the duodenum was observed (serosal S:R ratio, 1.2) with maximal inversion by the jejunum (serosal S:R ratio, 2.2), whereas inversion of R-FN was absent in the stomach.
Negative_regulation (inversion) of R-FN in stomach
4) Confidence 0.43 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1865366 Disease Relevance 0 Pain Relevance 0
We conclude that activation of PCF receptors can inhibit FN bursting during PEEP-induced phrenic apnea by inhibiting EI and I facial motoneuron discharge.
Negative_regulation (inhibit) of FN in phrenic associated with c fibre and sleep disorders
5) Confidence 0.41 Published 2008 Journal J. Appl. Physiol. Section Abstract Doc Link 17916674 Disease Relevance 0.19 Pain Relevance 0.73
For patients with contraindications for an FN block according to Winnie (e.g. vessel surgery in the groin) other more effective methods are available.


Negative_regulation (block) of FN
6) Confidence 0.38 Published 2005 Journal Anaesthesist Section Body Doc Link 15968551 Disease Relevance 0 Pain Relevance 0
CONCLUSION: An LFCN block is not a suitable alternative to an FN block for regional anaesthesia.
Negative_regulation (block) of FN in LFCN
7) Confidence 0.38 Published 2005 Journal Anaesthesist Section Body Doc Link 15968551 Disease Relevance 0 Pain Relevance 0
A new methodology, using electroimmunodiffusion, has been described for the determination of fibronectin (Fn) in plasma and CSF.
Negative_regulation (determination) of Fn in plasma
8) Confidence 0.27 Published 1991 Journal J. Neurol. Sci. Section Abstract Doc Link 1757796 Disease Relevance 0.39 Pain Relevance 0.14
A new methodology, using electroimmunodiffusion, has been described for the determination of fibronectin (Fn) in plasma and CSF.
Negative_regulation (determination) of fibronectin in plasma
9) Confidence 0.27 Published 1991 Journal J. Neurol. Sci. Section Abstract Doc Link 1757796 Disease Relevance 0.39 Pain Relevance 0.14
We investigated the effects of ulinastatin on the increase of granulocyte elastase (GEL) and the decrease of fibronectin (FN) after cardiopulmonary bypass (CPB) in 30 patients undergoing cardiopulmonary bypass.
Negative_regulation (decrease) of FN in granulocyte
10) Confidence 0.27 Published 1991 Journal Masui Section Abstract Doc Link 1766113 Disease Relevance 0 Pain Relevance 0.30
We investigated the effects of ulinastatin on the increase of granulocyte elastase (GEL) and the decrease of fibronectin (FN) after cardiopulmonary bypass (CPB) in 30 patients undergoing cardiopulmonary bypass.
Negative_regulation (decrease) of fibronectin in granulocyte
11) Confidence 0.27 Published 1991 Journal Masui Section Abstract Doc Link 1766113 Disease Relevance 0 Pain Relevance 0.30
FN decreased by 21-13% on the first postoperative day in three groups.
Negative_regulation (decreased) of FN
12) Confidence 0.17 Published 1991 Journal Masui Section Abstract Doc Link 1766113 Disease Relevance 0 Pain Relevance 0.43
MCL gene expression of collagen type I, collagen type III, collagen type V, fibronectin, decorin, biglycan, lysyl oxidase, matrix metalloproteinase-2, and tissue inhibitor of matrix metalloproteinase-1, measured by real-time quantitative PCR, demonstrated differential expression in the HLU-healing groups compared with Amb-healing groups at both the 3- and 7-wk time points.
Negative_regulation (inhibitor) of fibronectin in MCL associated with metalloproteinase
13) Confidence 0.06 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17699562 Disease Relevance 0.22 Pain Relevance 0.22
We recently demonstrated that specific inhibitors of Nox (the primary generator of superoxide anion in the kidney) decreased fibrogenesis in kidney allografts by decreasing fibronectin and phospho-smad2 and increasing E-cadherin levels [7].
Negative_regulation (decreasing) of fibronectin in kidney associated with fibrosis
14) Confidence 0.04 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 1.05 Pain Relevance 0.12
Streptozotocin (STZ)-induced diabetic rats treated with PFD and spironolactone showed both reversal in deposition of major ECM proteins, collagen and fibronectin, and a number of functional changes.
Negative_regulation (deposition) of fibronectin associated with diabetes mellitus
15) Confidence 0.03 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.87 Pain Relevance 0.23

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