INT157241

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.10
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
adipose tissue 4
fat 2
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 1 87.76 High High
Pain 43 73.68 Quite High
antagonist 44 5.00 Very Low Very Low Very Low
agonist 34 5.00 Very Low Very Low Very Low
cytokine 17 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
endometriosis 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
primary somatosensory cortex 6 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 41 99.84 Very High Very High Very High
Obesity 180 99.76 Very High Very High Very High
Recurrence 2 96.52 Very High Very High Very High
Stress 12 96.46 Very High Very High Very High
Infection 10 92.96 High High
INFLAMMATION 8 87.40 High High
Weight Gain 26 84.76 Quite High
Fibrosis 1 75.92 Quite High
Pain 36 73.68 Quite High
Appetite Loss 5 69.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, leptin release is suppressed in tuberculosis and
Negative_regulation (suppressed) of Localization (release) of leptin associated with mycobacterial infection
1) Confidence 0.56 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.82 Pain Relevance 0.04
The activation of the SNS with sleep restriction is one possibility since increased SNS activity inhibits the release of leptin from adipose tissue and may inhibit insulin release [51].
Negative_regulation (inhibits) of Localization (release) of leptin in adipose tissue associated with obesity
2) Confidence 0.50 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC2925323 Disease Relevance 0.52 Pain Relevance 0
However, chronic or frequent stress can desensitise the HPA axis such that cortisol remains elevated; over time this can lead to an increase in visceral body fat since cortisol promotes fat accumulation and also inhibits the release of leptin [49, 50, 58].
Negative_regulation (inhibits) of Localization (release) of leptin in fat associated with stress
3) Confidence 0.44 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC2925323 Disease Relevance 0.31 Pain Relevance 0
identify the LEP localization in the sensor space and focus on the analysis on one specific channel (in contrast to the analysis of all channels in the
Negative_regulation (identify) of Localization (localization) of LEP
4) Confidence 0.38 Published 2007 Journal Computational Intelligence and Neuroscience Section Body Doc Link PMC2271124 Disease Relevance 0.07 Pain Relevance 0.07
Moreover, in adipose tissue of women, the estrogen precursors; testosterone and dehydroepiandrosterone also induced an increase in leptin secretion, an effect that was prevented by the aromatase inhibitor letrozole.
Negative_regulation (prevented) of Localization (secretion) of leptin in adipose tissue associated with obesity
5) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.31 Pain Relevance 0
RESULTS: Compared with healthy volunteers, abstinent addicts showed disruptions in diurnal rhythms of hPER1 and hPER2 mRNA expression, along with disruptions in diurnal rhythms of cortisol, ACTH, beta-endorphin, leptin, and IL-2 release.
Negative_regulation (disruptions) of Localization (release) of leptin
6) Confidence 0.03 Published 2009 Journal Biol. Psychiatry Section Body Doc Link 19135652 Disease Relevance 0.07 Pain Relevance 0

General Comments

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