INT157244

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.40
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PER1) protein binding transcription factor activity (PER1) cytoplasm (PER1)
signal transducer activity (PER1)
Anatomy Link Frequency
nucleus 1
PER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 40 90.96 High High
agonist 97 81.36 Quite High
Serotonin 1 33.92 Quite Low
Neuropeptide 2 32.64 Quite Low
Pain 9 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 24 100.00 Very High Very High Very High
Diabetes Mellitus 26 99.84 Very High Very High Very High
Apoptosis 9 99.40 Very High Very High Very High
Dislocations 42 98.96 Very High Very High Very High
Colon Cancer 11 98.20 Very High Very High Very High
Myocardial Infarction 3 97.32 Very High Very High Very High
Stroke 3 96.28 Very High Very High Very High
Neurological Disease 1 94.48 High High
Cancer 22 77.68 Quite High
Left Ventricular Hypertrophy 4 75.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mammals, the Per and Cry gene products, which constitute the negative arm of the transcriptional feedback loop, form homo- and/or heteromeric complexes, translocate to the nucleus, and repress Clock/Bmal1-mediated transcription [17,18] in a temporal manner.
Localization (translocate) of Per in nucleus
1) Confidence 0.50 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.07 Pain Relevance 0
The use of a more constrained TKA design per se is not enough to prevent dislocation when there are persistent associated causes that must be addressed or when other conditions such as neurologic disorders are present.56



Localization (use) of per se associated with neurological disease and dislocations
2) Confidence 0.33 Published 2010 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2947733 Disease Relevance 0.28 Pain Relevance 0
If delay per se does not cause localization dominance, what causes the leading sound to dominate perception when the delay is short?
Neg (not) Localization (localization) of per se
3) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2571984 Disease Relevance 0 Pain Relevance 0
Moreover, while Cicaprost, Sin-1, BW245C or FK409 did not induce F-actin polymerization per se, they each significantly impaired U46619-induced F-actin polymerization (data not shown).
Localization (polymerization) of per se
4) Confidence 0.06 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.08
with LY 83583 did not interfere with its ability to mobilize [Ca2+]i per se (Compare Fig. 2A versus Fig. 8C), it partially inhibited desensitization of TP?
Localization (mobilize) of per se
5) Confidence 0.05 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
It is the AA release per se that leads to apoptosis [28].
Localization (release) of per se associated with apoptosis
6) Confidence 0.03 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1458335 Disease Relevance 0.52 Pain Relevance 0.15
In our opinion, the presence of hypertension per se in diabetic patients must be an indication to perform 24 h-ABPM.
Localization (presence) of per se associated with diabetes mellitus and hypertension
7) Confidence 0.02 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2928765 Disease Relevance 1.47 Pain Relevance 0
Several of these disruptions (hPER1, hPER2, ACTH, beta-endorphin, and IL-2) persisted for the 30-day testing period, as did elevation of 24-hour levels of cortisol and decreases in 24-hour IL-2 and TNF levels.
Localization (Several) of hPER1
8) Confidence 0.00 Published 2009 Journal Biol. Psychiatry Section Body Doc Link 19135652 Disease Relevance 0.07 Pain Relevance 0

General Comments

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