INT15725

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Context Info
Confidence 0.67
First Reported 1985
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 22
Disease Relevance 14.93
Pain Relevance 8.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fn1) extracellular region (Fn1) cell adhesion (Fn1)
proteinaceous extracellular matrix (Fn1) extracellular matrix organization (Fn1)
Anatomy Link Frequency
plasma 2
retina 2
liver 1
stellate cells 1
spinal cord 1
Fn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 10 100.00 Very High Very High Very High
chemokine 7 100.00 Very High Very High Very High
anesthesia 22 99.84 Very High Very High Very High
Peripheral nerve injury 15 99.72 Very High Very High Very High
rheumatoid arthritis 2 99.70 Very High Very High Very High
Morphine 13 99.56 Very High Very High Very High
Spinal cord 10 98.96 Very High Very High Very High
Arthritis 7 98.90 Very High Very High Very High
Inflammation 24 98.76 Very High Very High Very High
metalloproteinase 7 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 558 99.72 Very High Very High Very High
Rheumatoid Arthritis 3 99.70 Very High Very High Very High
Nervous System Injury 24 99.68 Very High Very High Very High
Congenital Anomalies 42 99.48 Very High Very High Very High
Pressure And Volume Under Development 7 98.98 Very High Very High Very High
Experimental Arthritis 6 98.90 Very High Very High Very High
INFLAMMATION 29 98.76 Very High Very High Very High
Arthralgia 1 98.16 Very High Very High Very High
Hypertension 186 97.82 Very High Very High Very High
Retinal Diseases 18 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we describe the influence of fibronectin on P2X4 receptor expression in microglia and the upregulation of fibronectin after peripheral nerve injury.
Positive_regulation (upregulation) of fibronectin in microglia associated with nervous system injury and peripheral nerve injury
1) Confidence 0.67 Published 2006 Journal Glia Section Abstract Doc Link 16534777 Disease Relevance 0.76 Pain Relevance 0.42
Moreover, Western blot examination of the spinal cord from a rat with spinal nerve injury indicated that fibronectin was upregulated on the ipsilateral side.
Positive_regulation (upregulated) of fibronectin in spinal cord associated with nervous system injury and spinal cord
2) Confidence 0.67 Published 2006 Journal Glia Section Abstract Doc Link 16534777 Disease Relevance 0.77 Pain Relevance 0.61
Taken together, our results suggest that spinal fibronectin is elevated after the peripheral nerve injury and it may be involved in the upregulation of the P2X4 receptor in microglia, which leads to the induction of neuropathic pain.
Positive_regulation (elevated) of fibronectin in peripheral nerve associated with nervous system injury, neuropathic pain and peripheral nerve injury
3) Confidence 0.67 Published 2006 Journal Glia Section Abstract Doc Link 16534777 Disease Relevance 0.88 Pain Relevance 0.63
A significant increase of plasma Fn was observed in each of the patients-group.
Positive_regulation (increase) of Fn in plasma
4) Confidence 0.45 Published 1991 Journal J. Neurol. Sci. Section Abstract Doc Link 1757796 Disease Relevance 0.60 Pain Relevance 0.31
The patients with rheumatoid arthritis showed a high level of EDA(+) FN in their plasma, and the EDA(+) FN level in plasma corresponded with changes in joint pain.
Positive_regulation (level) of FN in joint associated with pain, arthralgia and rheumatoid arthritis
5) Confidence 0.44 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7896431 Disease Relevance 0.48 Pain Relevance 0.20
When compared to normal animals, AA rats had significantly (P less than or equal to 0.01) increased: (1) splenic LAF activity (100% increase), (2) plasma Fn (58%), and (3) CRP (122%), as well as abnormally reduced levels of: (1) plasma albumin (53% reduction), and (2) iron (54%).
Positive_regulation (increased) of Fn in plasma associated with arthritis
6) Confidence 0.39 Published 1988 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 3143680 Disease Relevance 1.15 Pain Relevance 0.48
In the CSF an increase of Fn was observed predominantly in inflammatory processes but not in MS.
Positive_regulation (increase) of Fn associated with inflammation
7) Confidence 0.39 Published 1991 Journal J. Neurol. Sci. Section Abstract Doc Link 1757796 Disease Relevance 0.66 Pain Relevance 0.39
This is the first demonstration of an association between increased expression of p27Kip1 and fibronectin accumulation in retinal tissue, and could contribute to thickening of the retinal capillary basement membrane seen in diabetic retina.


Positive_regulation (accumulation) of fibronectin in retina associated with diabetes mellitus
8) Confidence 0.38 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.06 Pain Relevance 0
The accumulation of fibronectin in retinal tissue is a classic finding encountered early in the pathogenesis of diabetic retinal disease and in the microcirculation in models of hypertension [47-49].
Positive_regulation (accumulation) of fibronectin associated with diabetes mellitus, hypertension and retinal diseases
9) Confidence 0.38 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.20 Pain Relevance 0
Experimental studies have indicated that this accumulation of fibronectin in retinal tissue is simply an epiphenomenon of the diabetic state, but may be operative in sight-threatening diabetic retinopathy.
Positive_regulation (accumulation) of fibronectin associated with diabetes mellitus and diabetic retinopathy
10) Confidence 0.38 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.38 Pain Relevance 0
There was a close relationship between CPB time and increase of GEL in the control group (no ulinastatin given) (y = 18.5 x -833, r = 0.751), between CPB time and increase of FN in U1 (y = 1.4 x -163.4, r = 0.683) or increases of GEL and FN in the control group (y = 0.068 x -202.6, r = 0.812).
Positive_regulation (increases) of FN associated with anesthesia
11) Confidence 0.32 Published 1991 Journal Masui Section Abstract Doc Link 1766113 Disease Relevance 0 Pain Relevance 0.44
is a key factor that favours accumulation of collagen, laminin and fibronectin in the ECM [17].
Positive_regulation (accumulation) of fibronectin
12) Confidence 0.28 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.07 Pain Relevance 0.13
These findings were associated with enhanced expression of p27Kip1 and with the classic abnormalities of diabetic retina—i.e., fibronectin accumulation, increased expression of retinal vascular endothelial growth factor (VEGF), and blood-retinal barrier breakdown.


Positive_regulation (accumulation) of fibronectin in retina associated with diabetes mellitus and congenital anomalies
13) Confidence 0.28 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.74 Pain Relevance 0.07
It represents the principal source of Fn increase in the CSF.
Positive_regulation (increase) of Fn
14) Confidence 0.26 Published 1991 Journal J. Neurol. Sci. Section Abstract Doc Link 1757796 Disease Relevance 0.65 Pain Relevance 0.44
Agabiti-Rosei demonstrated that structural and functional changes in the microcirculation during arterial hypertension, e.g., remodeling of the extracellular matrix and accumulation of collagen and fibronectin, were associated with several neurohumoral and hormonal factors [49].
Positive_regulation (accumulation) of fibronectin in extracellular matrix associated with pressure and volume under development
15) Confidence 0.26 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.22 Pain Relevance 0
Concomitant diabetes and hypertension attenuated the proliferation of retinal cells, and it is associated with an increase in p27Kip1 expression, fibronectin accumulation, and blood-retinal barrier breakdown.
Positive_regulation (accumulation) of fibronectin in blood associated with diabetes mellitus and hypertension
16) Confidence 0.26 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2538494 Disease Relevance 0.99 Pain Relevance 0
Plasma samples collected from rat liver donors that had received DES showed similar effects on protein concentrations: significant decreases in concentration of plasminogen and antithrombin III were apparent with no significant changes in concentrations of fibrinogen, fibronectin, or albumin.
Neg (no) Positive_regulation (changes) of fibronectin in liver
17) Confidence 0.24 Published 1985 Journal Blood Section Abstract Doc Link 4016277 Disease Relevance 0 Pain Relevance 0.06
There was a close relationship between CPB time and increase of GEL in the control group (no ulinastatin given) (y = 18.5 x -833, r = 0.751), between CPB time and increase of FN in U1 (y = 1.4 x -163.4, r = 0.683) or increases of GEL and FN in the control group (y = 0.068 x -202.6, r = 0.812).
Positive_regulation (increase) of FN associated with anesthesia
18) Confidence 0.21 Published 1991 Journal Masui Section Abstract Doc Link 1766113 Disease Relevance 0 Pain Relevance 0.44
Morphine did not modulate the accumulation of laminin or fibronectin.
Positive_regulation (accumulation) of fibronectin associated with morphine
19) Confidence 0.21 Published 1997 Journal Nephron Section Abstract Doc Link 9346391 Disease Relevance 0.13 Pain Relevance 1.25
FN increased by 7-13% after CPB in U1 but decreased in other groups.
Positive_regulation (increased) of FN associated with anesthesia
20) Confidence 0.19 Published 1991 Journal Masui Section Abstract Doc Link 1766113 Disease Relevance 0 Pain Relevance 0.42

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