INT157265

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.15
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARG, PPARA) DNA binding (PPARG, PPARA) lipid metabolic process (PPARG, PPARA)
nucleus (PPARG, PPARA) small molecule metabolic process (PPARA) enzyme binding (PPARG)
Anatomy Link Frequency
skeletal muscle 1
PPARG (Homo sapiens)
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 96.04 Very High Very High Very High
Inflammation 1 91.36 High High
Pain 1 36.48 Quite Low
Disease Link Frequency Relevance Heat
Metabolic Syndrome 8 99.96 Very High Very High Very High
Insulin Resistance 3 99.50 Very High Very High Very High
Starvation 1 94.72 High High
INFLAMMATION 1 91.36 High High
Cardiovascular Disease 1 75.00 Quite High
Diabetes Mellitus 2 64.96 Quite High
Chronic Disease 1 59.16 Quite High
Disease 1 50.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further conclusions are that decreased adiponectin action and increased monocyte chemoattractant protein-1 (MCP-1) form a vicious adipokine network causing obesity-linked insulin resistance and metabolic syndrome; PPARgamma upregulates HMW adiponectin and PPARalpha upregulates AdipoRs; that dietary osmotin can serve as a naturally occurring adiponectin receptor agonist; and finally, that under starvation conditions, MMW adiponectin activates AMPK in hypothalamus, and promotes food intake, and at the same time HMW adiponectin activates AMPK in peripheral tissues, such as skeletal muscle, and stimulates fatty-acids combustion.
PPARgamma Positive_regulation (upregulates) of PPARalpha in skeletal muscle associated with starvation, agonist, metabolic syndrome and insulin resistance
1) Confidence 0.22 Published 2008 Journal Int J Obes (Lond) Section Abstract Doc Link 19136982 Disease Relevance 1.15 Pain Relevance 0.09

General Comments

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