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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKAA1) signal transduction (PRKAA1) nucleus (PRKAA1)
intracellular (PRKAA1) plasma membrane (Adipor1) response to stress (PRKAA1)
Anatomy Link Frequency
liver 1
Adipor1 (Mus musculus)
PRKAA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 93.80 High High
agonist 1 57.36 Quite High
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Metabolic Syndrome 8 98.56 Very High Very High Very High
Insulin Resistance 3 98.10 Very High Very High Very High
INFLAMMATION 1 93.80 High High
Chronic Disease 1 76.00 Quite High
Cardiovascular Disease 1 75.00 Quite High
Starvation 1 54.72 Quite High
Diabetes Mellitus 2 30.24 Quite Low
Disease 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have found that decreased high molecular weight (HMW) adiponectin plays a crucial and causal role in obesity-linked insulin resistance and metabolic syndrome; that AdipoR1 and AdipoR2 serve as the major AdipoRs in vivo; and that AdipoR1 activates the AMP kinase (AMPK) pathway and AdipoR2, the peroxisome proliferator-activated receptor alpha (PPARalpha) pathway in the liver, to increase insulin sensitivity and decrease inflammation.
AdipoR1 Positive_regulation (activates) of AMPK in liver associated with inflammation, metabolic syndrome and insulin resistance
1) Confidence 0.01 Published 2008 Journal Int J Obes (Lond) Section Abstract Doc Link 19136982 Disease Relevance 0.89 Pain Relevance 0.08

General Comments

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