INT157271

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.89 Pain Relevance 0.08

cytosol (PRKAA1) signal transduction (PRKAA1) nucleus (PRKAA1) intracellular (PRKAA1) plasma membrane (Adipor1) response to stress (PRKAA1)

Anatomy Link Frequency liver 1 Adipor1 (Mus musculus) PRKAA1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 1 93.80 agonist 1 57.36 Pain 1 25.00

Disease Link Frequency Relevance Heat Metabolic Syndrome 8 98.56 Insulin Resistance 3 98.10 INFLAMMATION 1 93.80 Chronic Disease 1 76.00 Cardiovascular Disease 1 75.00 Starvation 1 54.72 Diabetes Mellitus 2 30.24 Disease 1 25.00

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We have found that decreased high molecular weight (HMW) adiponectin plays a crucial and causal role in obesity-linked insulin resistance and metabolic syndrome; that AdipoR1 and AdipoR2 serve as the major AdipoRs in vivo; and that AdipoR1 activates the AMP kinase (AMPK) pathway and AdipoR2, the peroxisome proliferator-activated receptor alpha (PPARalpha) pathway in the liver, to increase insulin sensitivity and decrease inflammation.

AdipoR1 Positive_regulation (activates) of AMPK in liver associated with inflammation, metabolic syndrome and insulin resistance

1) Confidence 0.01 Published 2008 Journal Int J Obes (Lond) Section Abstract Doc Link 19136982 Disease Relevance 0.89 Pain Relevance 0.08

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