INT157275

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.13
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Adipoq) intracellular (PRKAA1) response to stress (PRKAA1)
cytoplasm (PRKAA1) cytosol (PRKAA1) signal transduction (PRKAA1)
Anatomy Link Frequency
skeletal muscle 1
PRKAA1 (Homo sapiens)
Adipoq (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 1 97.04 Very High Very High Very High
Inflammation 1 79.16 Quite High
Pain 1 58.88 Quite High
Disease Link Frequency Relevance Heat
Starvation 1 97.76 Very High Very High Very High
Metabolic Syndrome 8 93.86 High High
Insulin Resistance 3 93.40 High High
Diabetes Mellitus 2 87.36 High High
INFLAMMATION 1 79.16 Quite High
Cardiovascular Disease 1 75.00 Quite High
Disease 1 72.64 Quite High
Chronic Disease 1 46.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further conclusions are that decreased adiponectin action and increased monocyte chemoattractant protein-1 (MCP-1) form a vicious adipokine network causing obesity-linked insulin resistance and metabolic syndrome; PPARgamma upregulates HMW adiponectin and PPARalpha upregulates AdipoRs; that dietary osmotin can serve as a naturally occurring adiponectin receptor agonist; and finally, that under starvation conditions, MMW adiponectin activates AMPK in hypothalamus, and promotes food intake, and at the same time HMW adiponectin activates AMPK in peripheral tissues, such as skeletal muscle, and stimulates fatty-acids combustion.
AMPK Binding (activates) of adiponectin in skeletal muscle associated with starvation, agonist, metabolic syndrome and insulin resistance
1) Confidence 0.01 Published 2008 Journal Int J Obes (Lond) Section Abstract Doc Link 19136982 Disease Relevance 1.13 Pain Relevance 0.15

General Comments

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