INT157288

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cfl1) cytoskeleton (Cfl1) nucleus (Cfl1)
intracellular (Cfl1) cytoskeleton organization (Cfl1) cytoplasm (Cfl1)
Anatomy Link Frequency
neuronal 1
Cfl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 2 83.40 Quite High
Bile 4 78.00 Quite High
Lasting pain 1 72.44 Quite High
agonist 15 5.00 Very Low Very Low Very Low
alcohol 11 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 288 100.00 Very High Very High Very High
Injury 2 92.12 High High
Frailty 2 83.68 Quite High
Obesity 1 81.48 Quite High
Coronary Heart Disease 33 76.00 Quite High
Pain 1 72.44 Quite High
Atherosclerosis 49 69.44 Quite High
Targeted Disruption 10 52.88 Quite High
Cancer 2 51.68 Quite High
Renal Failure 1 46.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heterozygotes with a 40% decrease in CETP levels had a mean increase in HDL-C of 30% and no significant change in LDL-C levels, while homozygotes with complete loss of CETP levels had a greater than 100% increase in HDL-C and 40% decrease in LDL-C and Apo B levels (Inazu et al 1990; Koizumi et al 1991).
Positive_regulation (increase) of C of associated with disorder of lipid metabolism
1) Confidence 0.45 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.08 Pain Relevance 0.04
Here we show that transplantation of pre-differentiated ES cells activate both brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) signaling pathways in the host tissue, leading to activation of cAMP/PKA, phosporylation of cofilin and synapsin I, and promoting regenerative growth and neuronal survival.
Positive_regulation (activation) of cofilin in neuronal
2) Confidence 0.05 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19138107 Disease Relevance 0.41 Pain Relevance 0.15

General Comments

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