INT157289

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
neuronal 2
Syn1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 1 96.16 Very High Very High Very High
Spinal cord 3 83.40 Quite High
Lasting pain 1 72.44 Quite High
Nerve growth factor 1 46.04 Quite Low
medulla 15 5.00 Very Low Very Low Very Low
gABA 9 5.00 Very Low Very Low Very Low
Action potential 7 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 1 96.16 Very High Very High Very High
Injury 2 92.12 High High
Frailty 2 83.68 Quite High
Death 5 81.88 Quite High
Adhesions 1 78.80 Quite High
Targeted Disruption 4 73.52 Quite High
Pain 1 72.44 Quite High
Cognitive Disorder 1 38.96 Quite Low
Fasciculation 2 5.00 Very Low Very Low Very Low
Respiratory Failure 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that transplantation of pre-differentiated ES cells activate both brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) signaling pathways in the host tissue, leading to activation of cAMP/PKA, phosporylation of cofilin and synapsin I, and promoting regenerative growth and neuronal survival.
Positive_regulation (activation) of Phosphorylation (phosporylation) of synapsin I in neuronal
1) Confidence 0.28 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19138107 Disease Relevance 0.41 Pain Relevance 0.15
1 stimulates MAPK-dependent phosphorylation of synapsin, which in turn modulates synapsin distribution, and results in a reduced magnitude of synaptic depression [9].
Positive_regulation (stimulates) of Phosphorylation (phosphorylation) of synapsin associated with depression
2) Confidence 0.07 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0.33 Pain Relevance 0.05

General Comments

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