INT157293

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 4.07
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

translation factor activity, nucleic acid binding (EEF1A2) nucleus (EEF1A2) translation (EEF1A2)
GTPase activity (EEF1A2) cytoplasm (EEF1A2)
EEF1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 7 100.00 Very High Very High Very High
Chronic pancreatitis 3 99.44 Very High Very High Very High
deep brain stimulation 2 96.24 Very High Very High Very High
Inflammatory response 1 80.08 Quite High
Inflammation 2 35.84 Quite Low
cva 2 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 5 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
Parkinson's Disease 6 99.68 Very High Very High Very High
Pancreatitis 3 99.44 Very High Very High Very High
Pancreatic Cancer 18 99.40 Very High Very High Very High
Coronary Artery Disease 47 98.80 Very High Very High Very High
Cancer 6 94.84 High High
Atherosclerosis 6 92.16 High High
Disease 6 90.16 High High
INFLAMMATION 3 79.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Little or no expression of eEF1A2 was detected in normal human pancreatic and chronic pancreatitis tissues, whereas increased eEF1A2 expression occurred in 83% of the pancreatic cancers we studied.
Gene_expression (expression) of eEF1A2 associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.78 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19138673 Disease Relevance 0.79 Pain Relevance 0.10
Little or no expression of eEF1A2 was detected in normal human pancreatic and chronic pancreatitis tissues, whereas increased eEF1A2 expression occurred in 83% of the pancreatic cancers we studied.
Gene_expression (expression) of eEF1A2 associated with pancreatic cancer and chronic pancreatitis
2) Confidence 0.78 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19138673 Disease Relevance 0.80 Pain Relevance 0.10
Furthermore, using in vitro and in vivo model systems, we found that overexpression of eEF1A2 promoted cell growth, survival, and invasion in pancreatic cancer.
Gene_expression (overexpression) of eEF1A2 associated with pancreatic cancer
3) Confidence 0.78 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19138673 Disease Relevance 0.77 Pain Relevance 0.09
However, the effect of STN DBS on the pain in PD is only partially investigated.
Spec (investigated) Gene_expression (effect) of STN associated with parkinson's disease and pain
4) Confidence 0.65 Published 2008 Journal J. Neurol. Section Abstract Doc Link 19159059 Disease Relevance 0.91 Pain Relevance 0.44
More potent agents (eg, atorvastatin, rosuvastatin) were later developed, making it possible to achieve even more stringent target lipid goals (up to 55% reduction in LDL, up to 20% lowering in triglycerides, and up to 10% increase in HDL).11,12

Statins in the primary prevention of CHD

Gene_expression (achieve) of Statins associated with coronary artery disease and disorder of lipid metabolism
5) Confidence 0.65 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 0.80 Pain Relevance 0.04

General Comments

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