INT157295

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Context Info
Confidence 0.70
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.57
Pain Relevance 0.19

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translation factor activity, nucleic acid binding (EEF1A2) nucleus (EEF1A2) translation (EEF1A2)
GTPase activity (EEF1A2) cytoplasm (EEF1A2)
EEF1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 2 99.64 Very High Very High Very High
Pancreatic Cancer 12 99.04 Very High Very High Very High
Cancer 4 90.72 High High
Disease 2 86.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Little or no expression of eEF1A2 was detected in normal human pancreatic and chronic pancreatitis tissues, whereas increased eEF1A2 expression occurred in 83% of the pancreatic cancers we studied.
Positive_regulation (increased) of Gene_expression (expression) of eEF1A2 associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.70 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19138673 Disease Relevance 0.80 Pain Relevance 0.10
Furthermore, using in vitro and in vivo model systems, we found that overexpression of eEF1A2 promoted cell growth, survival, and invasion in pancreatic cancer.
Positive_regulation (overexpression) of Gene_expression (overexpression) of eEF1A2 associated with pancreatic cancer
2) Confidence 0.70 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19138673 Disease Relevance 0.77 Pain Relevance 0.09

General Comments

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