INT157301

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 3.20
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map1lc3a) cytoskeleton (Map1lc3a) cytoplasm (Map1lc3a)
Anatomy Link Frequency
fibroblasts 2
HeLa 1
Map1lc3a (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 9 99.84 Very High Very High Very High
addiction 2 48.64 Quite Low
analgesia 8 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
Enkephalin 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Buprenorphine 4 5.00 Very Low Very Low Very Low
halothane 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sulfatase Deficiency Disease 23 99.84 Very High Very High Very High
Stress 14 96.36 Very High Very High Very High
Death 28 95.56 Very High Very High Very High
Starvation 32 94.96 High High
Toxicity 125 88.68 High High
Neurodegenerative Disease 92 82.84 Quite High
Disease 133 81.28 Quite High
Mucopolysaccharidoses 1 80.56 Quite High
Apoptosis 41 75.48 Quite High
Pompes Disease 1 71.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased lethality and a decrease in GFP-LC3 levels in Atg7 deficient flies indicated that autophagy deficiency was deleterious during stress-inducing conditions such as starvation, oxidative stress and metamorphosis.
Negative_regulation (decrease) of GFP-LC3 associated with stress and starvation
1) Confidence 0.28 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 0.54 Pain Relevance 0
Analysis of the cell lines derived from MSD mice and their wild-type littermates show a decrease in the colocalization of the lysosomal marker, LAMP-1, and LC3 in MSD mouse embryonic fibroblasts (MEFs) [40,47], and the accumulation of autophagosomes resulting from impaired fusion of autophagosomes with lysosomes.
Negative_regulation (decrease) of LC3 in fibroblasts associated with multiple sulfatase deficiency disease
2) Confidence 0.18 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 1.02 Pain Relevance 0
Analysis of cell lines derived from MSD mice and their wildtype littermates showed a decrease in the colocalisation of the lysosomal marker, LAMP1, and LC3 in MSD mouse embryonic fibroblasts (MEFs).
Negative_regulation (decrease) of LC3 in fibroblasts associated with multiple sulfatase deficiency disease
3) Confidence 0.18 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 1.05 Pain Relevance 0
(F) Treatment of PC12 cells with PSA inhibitors also resulted in a decrease in LC3-II levels, a marker for autophagosomes.
Negative_regulation (decrease) of LC3
4) Confidence 0.12 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0 Pain Relevance 0
(H and I) In HeLa cells treated with PSA siRNA, LC3-II levels were decreased, whereas cells overexpressing PSA showed increased levels of LC3-II (J and K).
Negative_regulation (decreased) of LC3 in HeLa
5) Confidence 0.09 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0 Pain Relevance 0
LC3-II levels, which thus reflect autophagosome number when assayed relative to the loading control, actin, were decreased by PSA inhibitors (Fig. 6F and G) and also by transfection with PSA RNAi (Fig. 6H and I).
Negative_regulation (decreased) of LC3
6) Confidence 0.09 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0 Pain Relevance 0
PSA overexpression increased, and PSA knockdown or inhibition reduced microtubule-associated protein 1 light chain 3-II (LC3-II) levels and the amount of protein degradation sensitive to inhibitors of lysosomal function and autophagy.
Negative_regulation (reduced) of microtubule-associated protein 1 light chain 3
7) Confidence 0.09 Published 2010 Journal Human Molecular Genetics Section Abstract Doc Link PMC2972693 Disease Relevance 0.17 Pain Relevance 0
Pharmacological blockade or knockdown of ERK down-regulated LC3II.
Negative_regulation (down-regulated) of LC3II
8) Confidence 0.00 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19139269 Disease Relevance 0.42 Pain Relevance 0.41

General Comments

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