INT157302

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 11.31
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map1lc3a) cytoskeleton (Map1lc3a) cytoplasm (Map1lc3a)
Anatomy Link Frequency
neuronal 2
vesicle 2
Spleen 2
myoblasts 1
pyramidal cells 1
Map1lc3a (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 24 98.98 Very High Very High Very High
qutenza 9 89.36 High High
Hippocampus 50 78.92 Quite High
Pain 1 59.12 Quite High
addiction 4 57.64 Quite High
antagonist 13 52.36 Quite High
Dopamine 2 51.88 Quite High
Inflammation 5 48.40 Quite Low
medulla 26 45.76 Quite Low
cerebral cortex 8 44.32 Quite Low
Disease Link Frequency Relevance Heat
Stress 82 99.42 Very High Very High Very High
Multiple Sulfatase Deficiency Disease 33 98.64 Very High Very High Very High
Targeted Disruption 296 98.24 Very High Very High Very High
Disease 745 98.04 Very High Very High Very High
Muscle Disease 12 97.52 Very High Very High Very High
Parkinson's Disease 269 97.18 Very High Very High Very High
Death 119 93.32 High High
Bone Disease 12 93.20 High High
Apoptosis 103 92.88 High High
Lysosomal Storage Diseases 13 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 1C and D rilmenidine significantly increased LC3-II levels.
Positive_regulation (increased) of LC3-II
1) Confidence 0.66 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.11 Pain Relevance 0
Stable inducible PC12 cells expressing either wild-type (23Q) or expanded polyglutamine (74Q) huntingtin both showed a significant increase in LC3-II when treated with rilmenidine (Fig. 1A and B).
Positive_regulation (increase) of LC3-II
2) Confidence 0.66 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.32 Pain Relevance 0
We therefore used primary neuronal culture to show that treatment with rilmenidine increases LC3-II levels (Fig. 1E and F).
Positive_regulation (increases) of LC3-II in neuronal
3) Confidence 0.66 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0 Pain Relevance 0
Spleen cells from CCDD chimaeras showed increased levels of LC3 protein, as detected by Western blot analysis (fig 5b).
Positive_regulation (increased) of LC3 in Spleen
4) Confidence 0.53 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0 Pain Relevance 0
Previous studies have demonstrated that the detection of increased LC3-II levels in the brain is very difficult, as neurons appear to clear autophagosomes very efficiently (29).
Positive_regulation (increased) of LC3-II in brain
5) Confidence 0.44 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.06 Pain Relevance 0
This also allowed us to demonstrate that this increase in LC3-II levels results from an increase in synthesis rather than a decrease in degradation of autophagosomes, as increased levels were also seen in the presence of bafilomycin A1, an autophagy inhibitor that blocks autophagosome-lysosome fusion and therefore LC3-II degradation (27) (Fig. 1E and F).
Positive_regulation (increase) of LC3-II
6) Confidence 0.44 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0 Pain Relevance 0
Studies in patient myoblasts have revealed vacuoles and increased LC3 and autophagosome formation suggestive of impaired autophagy [9].
Positive_regulation (increased) of LC3 in myoblasts
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 1.76 Pain Relevance 0.06
Consistent with this possibility, in DLB cases Cathepsin D-immunoreactive lysosomes of normal size were scant, and pyramidal cells contained enlarged lysosomes (Figure 2H–J, N) and increased levels of LC3 immunoreactivity (Figure 2K–M, O) compared to control cases.
Positive_regulation (increased) of LC3 in pyramidal cells associated with parkinson's disease and pyramidal cell
8) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.84 Pain Relevance 0.09
-syn tg mice, rapamycin treatment resulted in increased levels of LC3 (Figure 8D–G) and Cathepsin D (Figure 8H–J, N) immunoreactivity.
Positive_regulation (increased) of LC3
9) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.16 Pain Relevance 0
By immunoblot analysis, levels of LC3 in the membrane fraction were increased and Cathepsin D was reduced in the ?
Positive_regulation (increased) of LC3
10) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.05 Pain Relevance 0.12
In addition, rapamycin increased the levels of LC3 and Cathepsin D immunoreactivity (Figure 8O, P).
Positive_regulation (increased) of LC3
11) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.32 Pain Relevance 0
Spleen cells from CCDD chimaeras showed increased levels of LC3 protein, as detected by Western blot analysis (fig 5b).
Positive_regulation (levels) of LC3 in Spleen
12) Confidence 0.35 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0 Pain Relevance 0
Indeed, an increase in autophagosome number and LC3-II levels can be observed in dynein-deficient transgenic mice [29,39].
Positive_regulation (increase) of LC3-II associated with targeted disruption
13) Confidence 0.33 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 0.99 Pain Relevance 0
Indeed a similar increase in autophagosome number and LC3-II levels along with decreased autophagic flux can be observed in dynein-defective transgenic cells and mice [34].


Positive_regulation (increase) of LC3 associated with targeted disruption
14) Confidence 0.24 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.68 Pain Relevance 0
Elevated LC3-II levels detected by immunoblotting and LC3-positive vesicles in neuronal tissue confirmed an accumulation of autophagosomes.
Positive_regulation (Elevated) of LC3-II in neuronal
15) Confidence 0.22 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 0.91 Pain Relevance 0.03
It increases LC3-II levels and vesicle numbers by impairing autophagosome-lysosome fusion and also reduces autophagosome synthesis by activating calpains (48).
Positive_regulation (increases) of LC3-II in vesicle
16) Confidence 0.22 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2856980 Disease Relevance 0.06 Pain Relevance 0.05
In the present study, we have demonstrated that LC3-II levels are significantly increased in cells expressing mutant CHMP2B.
Positive_regulation (increased) of LC3
17) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.20 Pain Relevance 0
A common cellular pathological feature in these diseases and their animal models is the manifestation of aberrant autophagic activity as evidenced by the accumulation of autophagosomes and increased levels of LC3-II, accompanied by neurodegeneration [41].
Positive_regulation (accumulation) of LC3 associated with disease
18) Confidence 0.16 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.62 Pain Relevance 0
A common cellular pathological feature in these diseases and their animal models is the manifestation of aberrant autophagic activity as evidenced by the accumulation of autophagosomes and increased levels of LC3-II, accompanied by neurodegeneration [41].
Positive_regulation (increased) of LC3 associated with disease
19) Confidence 0.16 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.61 Pain Relevance 0
The only known mammalian protein that specifically associates with the autophagosome membrane (as opposed to other vesicles) is MAP1 LC3 (microtubule-associated protein 1 light chain 3), which is post-translationally modified into cytosolic LC3-I, which conjugates with phosphatidylethanolamine upon autophagy induction to form autophagosome-associated LC3-II (13).
Positive_regulation (induction) of LC3-II in vesicles
20) Confidence 0.15 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2856980 Disease Relevance 0.22 Pain Relevance 0

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