INT157305

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 47
Total Number 47
Disease Relevance 18.04
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map1lc3a) cytoskeleton (Map1lc3a) cytoplasm (Map1lc3a)
Anatomy Link Frequency
liver 5
brain 5
neurons 3
neuronal 2
vesicle 2
Map1lc3a (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 35 98.60 Very High Very High Very High
qutenza 9 96.48 Very High Very High Very High
Central nervous system 8 91.24 High High
Pyramidal cell 72 89.68 High High
Hippocampus 84 79.32 Quite High
medulla 18 64.76 Quite High
cerebral cortex 8 63.32 Quite High
Inflammation 10 57.68 Quite High
addiction 12 57.28 Quite High
depression 14 56.56 Quite High
Disease Link Frequency Relevance Heat
Stress 187 100.00 Very High Very High Very High
Targeted Disruption 334 99.86 Very High Very High Very High
Infection 195 99.72 Very High Very High Very High
Cv Unclassified Under Development 22 98.60 Very High Very High Very High
Bacillus Anthracis Infection 196 98.36 Very High Very High Very High
Multiple Sulfatase Deficiency Disease 45 98.28 Very High Very High Very High
Parkinson's Disease 708 97.48 Very High Very High Very High
Starvation 71 95.24 Very High Very High Very High
Death 224 95.08 Very High Very High Very High
Neurodegenerative Disease 217 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cells were then infected at an MOI of 2 with adenoviruses expressing LC3-GFP fusion protein.
Gene_expression (expressing) of LC3
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.22 Pain Relevance 0
LC3-positive vesicle numbers or LC3-II levels (versus loading control) correlate with autophagosome numbers (27).
Gene_expression (levels) of LC3-II in vesicle
2) Confidence 0.64 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.36 Pain Relevance 0.08
This also allowed us to demonstrate that this increase in LC3-II levels results from an increase in synthesis rather than a decrease in degradation of autophagosomes, as increased levels were also seen in the presence of bafilomycin A1, an autophagy inhibitor that blocks autophagosome-lysosome fusion and therefore LC3-II degradation (27) (Fig. 1E and F).
Gene_expression (levels) of LC3-II
3) Confidence 0.64 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0 Pain Relevance 0
We assessed autophagosome numbers using the microtubule-associated protein 1 light chain (LC3) (27).
Gene_expression (using) of LC3
4) Confidence 0.64 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.52 Pain Relevance 0.17
LC3 is processed post-translationally into LC3-I, then converted to LC3-II, the only known protein that specifically associates with autophagosome membranes (28).
Gene_expression (processed) of LC3
5) Confidence 0.64 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.46 Pain Relevance 0.14
Previous studies have demonstrated that the detection of increased LC3-II levels in the brain is very difficult, as neurons appear to clear autophagosomes very efficiently (29).
Gene_expression (levels) of LC3-II in brain
6) Confidence 0.64 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.06 Pain Relevance 0
We assessed autophagosome numbers using the microtubule-associated protein 1 light chain (LC3) (27).
Gene_expression (using) of microtubule-associated protein 1 light chain
7) Confidence 0.64 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.52 Pain Relevance 0.17
Consistent with the immunohistochemical analysis (Figure 2), by immunoblot, levels of LC3 and Cathepsin D in the membrane fractions were reduced in the DLB cases compared to non-demented controls (Figure S1A, C).
Gene_expression (levels) of LC3 associated with parkinson's disease
8) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.89 Pain Relevance 0.07
By immunoblot analysis, levels of LC3 in the membrane fraction were increased and Cathepsin D was reduced in the ?
Gene_expression (levels) of LC3
9) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.05 Pain Relevance 0.12
LC3 staining was often high in cells with autofluorescent granules (Fig 5c, right panel), although since autofluorescence was visible in both red and green channels, it was not possible to definitively determine that LC3 was present in the autofluorescent granules themselves.
Gene_expression (present) of LC3
10) Confidence 0.59 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0.05 Pain Relevance 0
In contrast to the results obtained in liver and brain [19], LC3 protein expression in CCDWT was very low, and cathepsin D deficiency was associated with increased expression of both light (LC3II, membrane-bound) and heavy (LC3I, cytosolic) forms of LC3.
Gene_expression (expression) of LC3 in brain
11) Confidence 0.59 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0 Pain Relevance 0
As expected, no differences in LC3 expression were observed between the livers of CCDD and CCDWT (not shown).
Gene_expression (expression) of LC3 in livers
12) Confidence 0.59 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0 Pain Relevance 0
In contrast to the results obtained in liver and brain [19], LC3 protein expression in CCDWT was very low, and cathepsin D deficiency was associated with increased expression of both light (LC3II, membrane-bound) and heavy (LC3I, cytosolic) forms of LC3.
Gene_expression (expression) of LC3 in brain
13) Confidence 0.59 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0 Pain Relevance 0
In contrast to the results obtained in liver and brain [19], LC3 protein expression in CCDWT was very low, and cathepsin D deficiency was associated with increased expression of both light (LC3II, membrane-bound) and heavy (LC3I, cytosolic) forms of LC3.
Gene_expression (expression) of LC3II in brain
14) Confidence 0.59 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0 Pain Relevance 0
In contrast to the results obtained in liver and brain [19], LC3 protein expression in CCDWT was very low, and cathepsin D deficiency was associated with increased expression of both light (LC3II, membrane-bound) and heavy (LC3I, cytosolic) forms of LC3.
Gene_expression (expression) of LC3I in brain
15) Confidence 0.59 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0 Pain Relevance 0
To further consolidate the lethal toxin-induced autophagy, H9c2 cells were transfected with an adenovirus expressing the LC3-GFP fusion protein prior to the exposure of lethal toxin.
Gene_expression (expressing) of LC3
16) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.55 Pain Relevance 0.03
LC3-positive vesicle numbers or LC3-II levels (versus loading control) correlate with autophagosome numbers (27).
Gene_expression (levels) of LC3 in vesicle
17) Confidence 0.55 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.42 Pain Relevance 0.08
Consistent with the immunohistochemical analysis (Figure 2), by immunoblot, levels of LC3 and Cathepsin D in the membrane fractions were reduced in the DLB cases compared to non-demented controls (Figure S1A, C).
Gene_expression (levels) of LC3 associated with parkinson's disease
18) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.89 Pain Relevance 0.07
Double-labeling studies showed that mTor and LC3 were abundant in neurons displaying ?
Gene_expression (abundant) of LC3 in neurons
19) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.14 Pain Relevance 0.10
Compared to control mice, in the APP tg mice, levels of LC3 were elevated while levels of Cathepsin D were unchanged in the membrane fraction (Figure S2A, C).
Gene_expression (levels) of LC3
20) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.11 Pain Relevance 0.11

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