INT157306

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.21
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map1lc3a) cytoskeleton (Map1lc3a) cytoplasm (Map1lc3a)
Anatomy Link Frequency
Spleen 2
Map1lc3a (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 9 89.36 High High
cytokine 2 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
Clonidine 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 15 98.04 Very High Very High Very High
Death 11 93.32 High High
Apoptosis 11 92.88 High High
Neurodegenerative Disease 16 82.56 Quite High
Lysosomal Storage Diseases 5 80.72 Quite High
Stress 8 79.84 Quite High
Targeted Disruption 4 77.68 Quite High
Danon Disease 1 71.36 Quite High
Pompes Disease 1 52.16 Quite High
Multiple Sulfatase Deficiency Disease 5 38.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spleen cells from CCDD chimaeras showed increased levels of LC3 protein, as detected by Western blot analysis (fig 5b).
Positive_regulation (increased) of Positive_regulation (levels) of LC3 in Spleen
1) Confidence 0.35 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0 Pain Relevance 0
A common cellular pathological feature in these diseases and their animal models is the manifestation of aberrant autophagic activity as evidenced by the accumulation of autophagosomes and increased levels of LC3-II, accompanied by neurodegeneration [41].
Positive_regulation (accumulation) of Positive_regulation (increased) of LC3 associated with disease
2) Confidence 0.16 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.62 Pain Relevance 0
Knockdown of Ire1 down-regulated the DHC-induced Chop and LC3II and enhanced caspase-3 activation.
Positive_regulation (enhanced) of Positive_regulation (activation) of LC3II
3) Confidence 0.00 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19139269 Disease Relevance 0.60 Pain Relevance 0.44

General Comments

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