INT157342

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 21.27
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (S100A9) cytoplasm (S100A9) signal transducer activity (S100A9)
signal transduction (S100A9) extracellular space (S100A9) extracellular region (S100A9)
Anatomy Link Frequency
decidua 3
brains 2
feces 1
macrophages 1
leukocytes 1
S100A9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 382 100.00 Very High Very High Very High
Crohn's disease 8 99.40 Very High Very High Very High
spastic colon 202 99.24 Very High Very High Very High
cerebral cortex 2 96.92 Very High Very High Very High
abdominal pain 2 83.76 Quite High
Inflammatory response 30 75.76 Quite High
cytokine 98 70.32 Quite High
chemokine 37 68.60 Quite High
metalloproteinase 13 58.88 Quite High
rheumatoid arthritis 20 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 356 100.00 Very High Very High Very High
Sepsis 5 99.92 Very High Very High Very High
Disease 828 99.84 Very High Very High Very High
Alzheimer's Dementia 8 99.72 Very High Very High Very High
Recurrence 72 99.42 Very High Very High Very High
Leukocytosis 10 99.32 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

202 99.24 Very High Very High Very High
Infection 84 99.16 Very High Very High Very High
Inflammatory Bowel Disease 945 98.46 Very High Very High Very High
Eosinophilic Esophagitis 10 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a positive correlation between calprotectin concentration and CRP, and negative--with hemoglobin concentration.
Gene_expression (concentration) of calprotectin
1) Confidence 0.60 Published 2008 Journal Pol. Arch. Med. Wewn. Section Body Doc Link 19140565 Disease Relevance 0.11 Pain Relevance 0
Clinical utility of the assessment of fecal calprotectin in Le?
Gene_expression (assessment) of calprotectin
2) Confidence 0.52 Published 2008 Journal Pol. Arch. Med. Wewn. Section Title Doc Link 19140565 Disease Relevance 0.47 Pain Relevance 0.37
This apparent discrepancy might be explained by a compensatory increase in S100A8 and S100A9 expression by a non-epithelial cell type, as suggested by Tieu et al. [36], but this awaits further clarification.
Gene_expression (expression) of S100A9 in epithelial cell
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.76 Pain Relevance 0.07
Decreased expression of S100A8 and S100A9, members of the epidermal differentiation complex at chromosome 1q21, in epithelial cells from CRS patients with and without nasal polyps was recently reported [35], [36].
Gene_expression (expression) of S100A9 in nasal associated with rhinitis and chronic sinusitis
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.81 Pain Relevance 0.03
Expression and release of MRP8-MRP14 complexes by phagocytes correlates with disease activity in many inflammatory disorders.
Gene_expression (Expression) of MRP14 in phagocytes associated with inflammation and disease
5) Confidence 0.39 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.99 Pain Relevance 0.26
In our study of 65 IBD patients (14 CD and 51 UC) and 20 outpatients diagnosed with IBS according to Roma II criteria, fecal calprotectin was found to be strongly associated with colorectal inflammation, indicating the presence of organic disease.48
Gene_expression (found) of calprotectin associated with inflammatory bowel disease, inflammation, spastic colon and disease
6) Confidence 0.37 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.35 Pain Relevance 0.46
The authors also found that PMN-elastase and calprotectin levels were correlated with the endoscopically classified severity of inflammation but not the myeloperoxidase.34
Gene_expression (levels) of calprotectin associated with inflammation
7) Confidence 0.37 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 0.77 Pain Relevance 0.27
The results of the Clinical Activity Index (CAI), CRP and blood leukocytes in 134 UC patients found that endoscopic disease activity correlated closest with the presence of calprotectin.
Gene_expression (presence) of calprotectin in leukocytes associated with inflammatory bowel disease and disease
8) Confidence 0.37 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.58 Pain Relevance 0.44
However, in CD patients, only cases of colonic CD had a significant correlation between a positive calprotectin test and the probability of relapse (P= 0.02).52 Although fecal calprotectin levels are considered to change with age, 50 ?
Gene_expression (levels) of calprotectin associated with disease and recurrence
9) Confidence 0.37 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.38 Pain Relevance 0
In conclusion, fecal calprotectin was the only marker that reliably discriminated an inactive disease from mild, moderate and highly active diseases, highlighting its usefulness for monitoring activity.49
Gene_expression (fecal) of calprotectin associated with disease
10) Confidence 0.37 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.61 Pain Relevance 0.53
in a bivariate logistic regression model including either the numbers of CD68+ sublining macrophages, CD163+, MPR8+, MRP14+ macrophages, or CD3+ T cells, these cellular markers were no longer significantly associated with response.
Gene_expression (macrophages) of MRP14 in macrophages
11) Confidence 0.34 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564801 Disease Relevance 0.08 Pain Relevance 0
Moreover, there was a weak correlation between rectal NO levels, disease activity and the number of loose stools in IBD patients (Spearman’s rho 0.37 and 0.51, respectively; p <0.05); interestingly, there was no correlation between NO and calprotectin levels.62
Gene_expression (levels.62) of calprotectin associated with inflammatory bowel disease and disease
12) Confidence 0.33 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.51 Pain Relevance 0.19
The leukocyte proteins calprotectin, lactoferrin, lysozyme, myeloperoxidase, and PMN-elastase were compared in fecal samples of three consecutive feces (e.g., three days) in 40 healthy persons, 39 patients with chronic IBD (21 with CD and 18 with UC) and 40 patients with IBS.
Gene_expression (compared) of calprotectin in feces associated with inflammatory bowel disease, spastic colon and disease
13) Confidence 0.33 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.01 Pain Relevance 0.40
However, in CD patients, only cases of colonic CD had a significant correlation between a positive calprotectin test and the probability of relapse (P= 0.02).52 Although fecal calprotectin levels are considered to change with age, 50 ?
Gene_expression (test) of calprotectin associated with disease and recurrence
14) Confidence 0.33 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.36 Pain Relevance 0
Calgranulin B (S100A9), an inflammation-associated protein was reported to be expressed in AD but not in normal human brains [37].
Gene_expression (expressed) of Calgranulin B in brains associated with inflammation and disease
15) Confidence 0.30 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2848146 Disease Relevance 1.75 Pain Relevance 0.10
Calgranulin B (S100A9), an inflammation-associated protein was reported to be expressed in AD but not in normal human brains [37].
Gene_expression (expressed) of S100A9 in brains associated with inflammation and disease
16) Confidence 0.30 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2848146 Disease Relevance 1.74 Pain Relevance 0.10
It was found, that calgranulin B (expressed by macrophages and by epithelial cells in acutely inflamed tissues) and a unique restrictive fragment of Insulin-like Growth Factor Binding Protein 1 (IGFBP-1) – synthesized by both fetal membranes and maternal decidua, were differentially expressed in the amniotic fluid and sera during intra-amniotic infection prior to the appearance of clinical symptoms.
Gene_expression (expressed) of calgranulin B in decidua associated with infection
17) Confidence 0.02 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892066 Disease Relevance 0.60 Pain Relevance 0.03
It was found, that calgranulin B (expressed by macrophages and by epithelial cells in acutely inflamed tissues) and a unique restrictive fragment of Insulin-like Growth Factor Binding Protein 1 (IGFBP-1) – synthesized by both fetal membranes and maternal decidua, were differentially expressed in the amniotic fluid and sera during intra-amniotic infection prior to the appearance of clinical symptoms.
Gene_expression (synthesized) of calgranulin B in decidua associated with infection
18) Confidence 0.02 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892066 Disease Relevance 0.74 Pain Relevance 0.06
It was found, that calgranulin B (expressed by macrophages and by epithelial cells in acutely inflamed tissues) and a unique restrictive fragment of Insulin-like Growth Factor Binding Protein 1 (IGFBP-1) – synthesized by both fetal membranes and maternal decidua, were differentially expressed in the amniotic fluid and sera during intra-amniotic infection prior to the appearance of clinical symptoms.
Gene_expression (expressed) of calgranulin B in decidua associated with infection
19) Confidence 0.02 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892066 Disease Relevance 0.81 Pain Relevance 0.07

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