INT157357

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 5.18
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL2RA) plasma membrane (IL2RA)
Anatomy Link Frequency
IL2R 2
plasma 1
juvenile 1
vesicle 1
T cells 1
IL2RA (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 55 99.84 Very High Very High Very High
Arthritis 158 99.60 Very High Very High Very High
Potency 3 98.92 Very High Very High Very High
tolerance 13 98.12 Very High Very High Very High
cytokine 57 95.68 Very High Very High Very High
Paracetamol 9 84.56 Quite High
corticosteroid 43 65.00 Quite High
cINOD 1 61.68 Quite High
methotrexate 2 57.76 Quite High
Inflammatory marker 3 44.16 Quite Low
Disease Link Frequency Relevance Heat
Cancer 32 100.00 Very High Very High Very High
Necrosis 6 100.00 Very High Very High Very High
Rheumatoid Arthritis 55 99.84 Very High Very High Very High
Juvenile Chronic Polyarthritis 145 99.60 Very High Very High Very High
Metastasis 5 98.20 Very High Very High Very High
Autoimmune Disease 20 97.52 Very High Very High Very High
Diphtheria 21 92.68 High High
Disease 89 90.56 High High
Organ Transplantation 4 89.48 High High
Arthritis 13 81.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once bound to the IL2R, denileukin diftitox is internalized via receptor-mediated endocytosis in an acidified vesicle.
IL2R Binding (bound) of in vesicle
1) Confidence 0.44 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.68 Pain Relevance 0.04
We know now that the IL2R is a complex comprised by three parts: the alpha chain (CD25) which is required for high affinity binding, the beta chain (CD122) which participates in IL2 and IL15 signal transduction, and the common gamma chain (CD132) which participates in downstream signal transduction of IL2 and other cytokines.11–14
IL2R Binding (complex) of in IL2R associated with cytokine
2) Confidence 0.34 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.22 Pain Relevance 0.04
This resulted in a 5-fold greater affinity for IL2R and a 10-fold increase in potency.25,26 The resulting DAB389-IL2 fusion protein toxin is otherwise known as denileukin diftitox.
IL2R Binding (affinity) of in IL2R associated with potency
3) Confidence 0.32 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.27 Pain Relevance 0.18
In juvenile idiopathic arthritis (JIA), another complex genetic autoimmune disease, the strategy of using information from autoimmune disease GWAS or candidate gene studies to help in the search for novel JIA susceptibility loci has been successful, with confirmed association with two genes, PTPN22 and IL2RA.
IL2RA Binding (association) of in juvenile associated with autoimmune disease, juvenile chronic polyarthritis and arthritis
4) Confidence 0.32 Published 2010 Journal Annals of the Rheumatic Diseases Section Abstract Doc Link PMC2935325 Disease Relevance 1.87 Pain Relevance 0.63
-chain of its receptor, CD25, and the CD40 Ligand.
CD25 Binding (receptor) of
5) Confidence 0.11 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0
The CD25 molecule presented itself as a tempting target for drug development, due to its IL-2 specificity and its presence only on T cells preactivated with other cytokines, such as IL-1, IL-6, and tumor necrosis factor.
CD25 Binding (target) of in T cells associated with necrosis, cancer and cytokine
6) Confidence 0.08 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721359 Disease Relevance 0.41 Pain Relevance 0.08
The column selectively bound soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and sTNF-R2) and soluble interleukin-2 receptors (sIL2-R) by lowering plasma levels in patients with metastatic cancer.
sIL2-R Binding (bound) of in plasma associated with necrosis, cancer and metastasis
7) Confidence 0.07 Published 2008 Journal Ther Apher Dial Section Abstract Doc Link 19140848 Disease Relevance 0.54 Pain Relevance 0
Lastly, sIL2R was most associated with the more severe forms of JIA namely; systemic, RF+ and RF- polyarticular JIA.


sIL2R Binding (associated) of associated with arthritis
8) Confidence 0.01 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.19 Pain Relevance 0.66

General Comments

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