INT157362

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.27
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK9) nucleoplasm (MAPK9) mitochondrion (MAPK9)
nucleus (MAPK9) transcription factor binding (MAPK9) response to stress (MAPK9)
Anatomy Link Frequency
cleavage 1
MAPK9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 13 99.24 Very High Very High Very High
rheumatoid arthritis 32 95.88 Very High Very High Very High
metalloproteinase 3 84.36 Quite High
cINOD 14 83.04 Quite High
cytokine 14 70.04 Quite High
antagonist 2 10.72 Low Low
Inflammation 14 5.00 Very Low Very Low Very Low
Arthritis 7 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 123 99.60 Very High Very High Very High
Shock 29 99.08 Very High Very High Very High
Rheumatoid Arthritis 32 95.88 Very High Very High Very High
Nerve Sheath Neoplasms 44 93.80 High High
Colon Cancer 61 92.32 High High
Cancer 132 89.00 High High
Metastasis 17 87.28 High High
Stress 94 81.60 Quite High
Synovitis 5 78.60 Quite High
Increased Venous Pressure Under Development 2 60.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MENK-induced apoptosis was abrogated by a c-Jun N-terminal kinase inhibitor.
Negative_regulation (inhibitor) of c-Jun N-terminal kinase associated with enkephalin and apoptosis
1) Confidence 0.35 Published 2009 Journal Cancer Sci. Section Abstract Doc Link 19141128 Disease Relevance 1.35 Pain Relevance 1.06
Inhibition of SAPK (SP600125) most robustly up-regulated ATF3 mRNA expression (Figure 2A).
Negative_regulation (Inhibition) of SAPK
2) Confidence 0.20 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.59 Pain Relevance 0
The fact that recent progress in pharmacological research has led to the development of selective inhibitors of all three MAPK/SAPK pathways will provide further insights into the role of each of these pathways in the pathogenesis of RA.
Negative_regulation (inhibitors) of SAPK associated with rheumatoid arthritis
3) Confidence 0.17 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 0.70 Pain Relevance 0.22
Furthermore, Sulindac metabolites showed low activation of caspase-3, a common downstream regulator of SAPK/JNK [23,33].
Negative_regulation (regulator) of SAPK
4) Confidence 0.09 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.68 Pain Relevance 0.16
In addition, cleavage of caspase-3, a common downstream regulator of SAPK/JNK [23,34], was assayed.
Negative_regulation (regulator) of SAPK in cleavage
5) Confidence 0.09 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.43 Pain Relevance 0
This correlated with inhibition of the downstream target of MEKK1 activity, i.e. the SAPK/JNK kinase.
Negative_regulation (inhibition) of SAPK
6) Confidence 0.09 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2071920 Disease Relevance 0.05 Pain Relevance 0
Thus PEITC blocks activation of MEKK1 by osmotic shock, and this inhibition exactly correlates with inhibition of SAPK.
Negative_regulation (inhibition) of SAPK associated with shock
7) Confidence 0.09 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.48 Pain Relevance 0

General Comments

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