INT157364

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.33
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK9) nucleoplasm (MAPK9) mitochondrion (MAPK9)
nucleus (MAPK9) transcription factor binding (MAPK9) response to stress (MAPK9)
Anatomy Link Frequency
MOLT-4 2
MAPK9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 13 96.80 Very High Very High Very High
Inflammation 5 82.24 Quite High
Dorsal horn 1 8.60 Low Low
Spinal cord 39 5.00 Very Low Very Low Very Low
Nerve growth factor 11 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 22 99.48 Very High Very High Very High
Shock 6 99.32 Very High Very High Very High
Cancer 12 94.76 High High
Colon Cancer 8 92.20 High High
Stress 11 90.00 High High
Metastasis 3 87.84 High High
INFLAMMATION 5 82.24 Quite High
Injury 33 64.04 Quite High
Spinal Cord Injury 53 42.88 Quite Low
Death 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, it increased the phosphorylation level of c-Jun N-terminal kinase and induced apoptosis in MOLT-4 cells.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of c-Jun N-terminal kinase in MOLT-4 associated with apoptosis
1) Confidence 0.56 Published 2009 Journal Cancer Sci. Section Abstract Doc Link 19141128 Disease Relevance 1.34 Pain Relevance 1.05
At 7 days post-transplant SAPK phosphorylation increased in hMNP-transplanted animals, however, no significant difference was observed between groups.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of SAPK
2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.47 Pain Relevance 0.10
As expected, we observed that PEITC specifically inhibited the activating phosphorylation of SAPK induced by hyperosmotic shock using sorbitol (Figure 8, Panel A), consistent with the inhibition seen by in vitro kinase assay.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of SAPK associated with shock
3) Confidence 0.10 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.52 Pain Relevance 0

General Comments

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