INT157366

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.43
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNMA1) transmembrane transport (KCNMA1)
Anatomy Link Frequency
nerve 2
KCNMA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 13 100.00 Very High Very High Very High
Nerve growth factor 1 98.94 Very High Very High Very High
adenocard 1 97.90 Very High Very High Very High
Inflammatory mediators 2 97.54 Very High Very High Very High
Paroxysmal extreme pain disorder 32 93.84 High High
Kinase C 1 92.04 High High
qutenza 1 85.36 High High
Inflammation 4 84.52 Quite High
Migraine 1 76.60 Quite High
agonist 1 75.12 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 1 99.52 Very High Very High Very High
INFLAMMATION 5 97.34 Very High Very High Very High
Hereditary Angioedema 1 96.56 Very High Very High Very High
Somatoform Disorder 32 93.84 High High
Coagulation Disorder 1 86.32 High High
Endotoxemia 1 85.60 High High
Hypertension 1 85.08 High High
Headache 1 76.60 Quite High
Pancreatitis 1 76.08 Quite High
Overactive Bladder 1 75.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In others, the inability of angiotensin converting enzyme (ACE) to degrade BK leads to elevated BK levels and edema in patients on ACE inhibitors.
Positive_regulation (leads) of Positive_regulation (elevated) of BK associated with pressure and volume under development and bradykinin
1) Confidence 0.05 Published 2009 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 19689262 Disease Relevance 0.61 Pain Relevance 0.60
Moreover, there is also evidence that various inflammatory mediators such as adenosine triphosphate (ATP), bradykinin, nerve growth factor (NGF) or prostaglandin E(2) (PGE(2)) may indirectly lead to activation of the TRPV1 channel via activation of their respective receptors.
Spec (may) Positive_regulation (lead) of Positive_regulation (activation) of channel in nerve associated with adenocard, inflammatory mediators, nerve growth factor and bradykinin
2) Confidence 0.01 Published 2009 Journal Pulm Pharmacol Ther Section Abstract Doc Link 19141328 Disease Relevance 1.45 Pain Relevance 0.80
Thus, mutations in S4-S5 linkers are expected to affect activation, consistent with the findings that mutations in these linkers of NaV1.7 induce significant hyperpolarizing shifts of channel activation [[17,20,21], and this study].
Positive_regulation (induce) of Positive_regulation (activation) of channel
3) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0.37 Pain Relevance 0.34

General Comments

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