INT157399

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 2.30
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Pcyt1b) biosynthetic process (Pcyt1b) nucleotidyltransferase activity (Pcyt1b)
Anatomy Link Frequency
medulla 2
pons 2
dorsal 1
nerve 1
Pcyt1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal column 26 100.00 Very High Very High Very High
Calcitonin gene-related peptide 4 99.76 Very High Very High Very High
Spinal cord 411 99.74 Very High Very High Very High
bDMF 426 98.80 Very High Very High Very High
medulla 178 97.56 Very High Very High Very High
Sciatic nerve 136 94.20 High High
Raphe 45 93.88 High High
unmyelinated 2 92.40 High High
anesthesia 12 81.52 Quite High
Visceral pain 2 79.12 Quite High
Disease Link Frequency Relevance Heat
Spinal Cord Injury 89 99.88 Very High Very High Very High
Injury 92 95.48 Very High Very High Very High
Vibrio Infection 21 94.72 High High
Nociception 2 87.00 High High
Sciatic Neuropathy 64 86.80 High High
Body Weight 6 83.44 Quite High
Frailty 5 76.32 Quite High
Autonomic Dysreflexia 3 75.00 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 75.00 Quite High
Syndrome 2 73.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, CTb-labeled pelvic afferent fibers were co-localized with CGRP(+) fibers, but not with RT97(+) fibers.
Neg (not) Localization (localized) of CTb associated with calcitonin gene-related peptide
1) Confidence 0.69 Published 2009 Journal Neuroscience Section Abstract Doc Link 19146928 Disease Relevance 0.86 Pain Relevance 0.58
Every 6th section was collected and either mounted onto gelatin-coated slides or left free floating for visualisation of CTB immunoreactivity.
Localization (visualisation) of CTB
2) Confidence 0.49 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919385 Disease Relevance 0 Pain Relevance 0.15
After injection of CTB into the rostral cervical cord of the G140 fetus, CTB labelled cells were found within identifiable nuclei in the medulla and pons, as well as throughout the reticular formation, in the vestibular nucleus, raphe complex, red nucleus, and the nucleus of the solitary tract [48].
Localization (injection) of CTB in pons associated with medulla and raphe
3) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919385 Disease Relevance 0 Pain Relevance 0.16
After injection of CTB into the rostral cervical cord of the G140 fetus, CTB labelled cells were found within identifiable nuclei in the medulla and pons, as well as throughout the reticular formation, in the vestibular nucleus, raphe complex, red nucleus, and the nucleus of the solitary tract [48].
Localization (injection) of CTB in pons associated with medulla and raphe
4) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919385 Disease Relevance 0 Pain Relevance 0.16
After spinal cord injury, the transport of CTB was interrupted and no CTB labeled nerve terminals were observed in the gracile nucleus indicating the complete injury of ascending sensory neurons.
Localization (transport) of CTB in nerve associated with injury and spinal cord
5) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.44 Pain Relevance 0.46
CTB labeling of dorsal column axons in preconditioning lesioned rats treated with NSS or the antiserum to BDNF
Localization (treated) of CTB in dorsal associated with bdmf and dorsal column
6) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.44 Pain Relevance 0.44
For simultaneous visualization of FGF1 and CTb, we employed a double immunofluorescence method using the mouse anti-FGF1 antibody and goat anti-choleragenoid antibody.
Localization (visualization) of CTb
7) Confidence 0.16 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831852 Disease Relevance 0.24 Pain Relevance 0.13
Double immunofluorescence for FGF1 and CTb
Localization (immunofluorescence) of CTb
8) Confidence 0.16 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831852 Disease Relevance 0.25 Pain Relevance 0.13
After injection of CTB into the rostral cervical cord of the G140 fetus, CTB labelled cells were found within identifiable nuclei in the medulla and pons, as well as throughout the reticular formation, in the vestibular nucleus, raphe complex, red nucleus, and the nucleus of the solitary tract [48].
Localization (injection) of CTB in medulla associated with medulla and raphe
9) Confidence 0.15 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919385 Disease Relevance 0 Pain Relevance 0.16
After injection of CTB into the rostral cervical cord of the G140 fetus, CTB labelled cells were found within identifiable nuclei in the medulla and pons, as well as throughout the reticular formation, in the vestibular nucleus, raphe complex, red nucleus, and the nucleus of the solitary tract [48].
Localization (injection) of CTB in medulla associated with medulla and raphe
10) Confidence 0.15 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919385 Disease Relevance 0 Pain Relevance 0.16

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