INT157400

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 7.30
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tnfrsf18) plasma membrane (Tnfrsf18)
Anatomy Link Frequency
blood 1
nerve 1
Tnfrsf18 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 125 98.12 Very High Very High Very High
aspirin 15 98.08 Very High Very High Very High
Nerve growth factor 1 97.40 Very High Very High Very High
tolerance 16 92.96 High High
cytokine 94 86.48 High High
Inflammation 83 85.56 High High
agonist 5 73.96 Quite High
Demyelination 24 68.72 Quite High
Pain 2 67.84 Quite High
Sciatica 39 64.96 Quite High
Disease Link Frequency Relevance Heat
Cancer 100 100.00 Very High Very High Very High
Necrosis 69 100.00 Very High Very High Very High
Intervertebral Disk Displacement 117 99.84 Very High Very High Very High
Demyelinating Disease 169 98.12 Very High Very High Very High
Autoimmune Disease 157 95.40 Very High Very High Very High
Spinal Fractures 52 94.04 High High
Multiple Sclerosis 70 92.64 High High
Disease Progression 13 90.20 High High
INFLAMMATION 94 85.56 High High
Graft Vs Host Disease 5 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phenotype of CD4(+)CD25(+) Treg cells, including the expressions of CD44, CD45RB, CD62L, CD69, GITR and CTLA-4, did not show detectable changes in ASA-treated mice.
Gene_expression (expressions) of GITR associated with aspirin
1) Confidence 0.39 Published 2009 Journal Transpl. Immunol. Section Abstract Doc Link 19146957 Disease Relevance 0.21 Pain Relevance 0.69
The purpose of the present study is to investigate whether the overexpression of AITR and AITRL might be associated with lumbar disc herniation.


Gene_expression (overexpression) of AITR
2) Confidence 0.38 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628152 Disease Relevance 0.68 Pain Relevance 0
This may be the first study to demonstrate that patients with lumbar disc herniation have a significantly increased AITR and AITRL expression in herniated disc tissue and in peripheral blood.
Gene_expression (expression) of AITR in blood associated with intervertebral disk displacement
3) Confidence 0.38 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.42 Pain Relevance 0
The disc cells and PBMC were subjected to two-color flow cytometry in order to determine the expression profiles of AITR and AITRL.
Spec (determine) Gene_expression (expression) of AITR
4) Confidence 0.33 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0 Pain Relevance 0
The expression levels of AITR and AITRL were investigated by flow cytometric analysis, confocal laser scanning microscopy, immunohistochemistry and by reverse transcriptase-polymerase chain reaction (RT-PCR).
Spec (investigated) Gene_expression (expression) of AITR
5) Confidence 0.33 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628152 Disease Relevance 0.61 Pain Relevance 0
The purpose of the present study is to determine if AITR and AITRL are overexpressed in symptomatic lumbar disc herniation patients.


Gene_expression (overexpressed) of AITR
6) Confidence 0.33 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.67 Pain Relevance 0.06
This phenomenon was not observed in healthy control groups, suggesting that the increased expression of AITR and AITRL might play a specific pathogenic role in lumbar disc herniation.
Gene_expression (expression) of AITR
7) Confidence 0.33 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.41 Pain Relevance 0
strongly induce expression of TNFRSF18/glucocorticoid-induced TNFR-related (GITR) gene, which leads to induction of the enzyme controlling de novo NAD biosynthesis, indoleamine 2,3-dioxygenase (IDO).
Gene_expression (expression) of GITR
8) Confidence 0.30 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 1.07 Pain Relevance 0.43
strongly induce expression of TNFRSF18/glucocorticoid-induced TNFR-related (GITR) gene, which leads to induction of the enzyme controlling de novo NAD biosynthesis, indoleamine 2,3-dioxygenase (IDO).
Gene_expression (expression) of TNFR-related
9) Confidence 0.30 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 1.07 Pain Relevance 0.43
The aim of the present study is to investigate whether AITR and AITRL are overexpressed in lumbar disc herniation patients.
Gene_expression (overexpressed) of AITR
10) Confidence 0.29 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.30 Pain Relevance 0
There was increased expression of AITRL and slightly increased expression of AITR on the herniated disc cells, but not in the controls (Fig. 6).
Gene_expression (expression) of AITR associated with intervertebral disk displacement
11) Confidence 0.29 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.25 Pain Relevance 0
The expression of AITRL mRNA was in creased in the patients when compared to the controls, but there was no difference in AITR mRNA expression between the two groups (Fig. 7).
Gene_expression (expression) of AITR mRNA
12) Confidence 0.29 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.25 Pain Relevance 0
Serum levels of soluble AITR and AITRL were measured by an enzyme-linked immunosorbent assay (ELISA).
Gene_expression (levels) of AITR
13) Confidence 0.26 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.23 Pain Relevance 0.15
AITR and AITRL expression was apparent on the herniated disc cells (Fig. 5), but not on the control discs.


Gene_expression (expression) of AITR associated with intervertebral disk displacement
14) Confidence 0.26 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.18 Pain Relevance 0
The herniation patients had significantly higher levels of AITR and AITRL than did the controls; these levels are expressed as the percentages of cells from the disc tissue (mean ± SD), AITR: 12.15 ± 5.16% versus 6.84 ± 1.76%, p < 0.05, AITRL: 39.43 ± 8.57 versus 18.71 ± 5.56%, p < 0.05) (Fig. 1).
Gene_expression (expressed) of AITR
15) Confidence 0.26 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.20 Pain Relevance 0.14
The herniation patients had significantly higher levels of AITR and AITRL than did the controls; these levels are expressed as the percentages of cells from the disc tissue (mean ± SD), AITR: 12.15 ± 5.16% versus 6.84 ± 1.76%, p < 0.05, AITRL: 39.43 ± 8.57 versus 18.71 ± 5.56%, p < 0.05) (Fig. 1).
Gene_expression (expressed) of AITR
16) Confidence 0.26 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.20 Pain Relevance 0.13
Tregs also express the glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known as TNFRSF18), a member of the tumor necrosis factor-nerve growth factor (TNF-NGF) receptor gene superfamily, which plays a key role in dominant immunological self-tolerance [45].
Gene_expression (express) of GITR in nerve associated with necrosis, nerve growth factor, cancer and tolerance
17) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.55 Pain Relevance 0.10

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