INT157401

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 15.43
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Ctla4) plasma membrane (Ctla4)
Anatomy Link Frequency
T cell 7
macrophage 1
myeloid cells 1
eosinophils 1
effector T lymphocytes 1
Ctla4 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 200 99.98 Very High Very High Very High
aspirin 15 98.52 Very High Very High Very High
tolerance 63 96.08 Very High Very High Very High
Dopamine 2 82.20 Quite High
chemokine 24 82.00 Quite High
Inflammation 129 79.12 Quite High
abatacept 7 78.32 Quite High
cytokine 139 78.12 Quite High
spinal inflammation 137 74.08 Quite High
Arthritis 39 72.28 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 202 99.98 Very High Very High Very High
Glioma 47 99.72 Very High Very High Very High
Immunotherapy Of Cancer 15 98.62 Very High Very High Very High
Mycobacterial Infection 178 98.08 Very High Very High Very High
Lymphoproliferative Disease 7 98.00 Very High Very High Very High
Hookworm Infection 35 97.96 Very High Very High Very High
Cancer 989 97.20 Very High Very High Very High
Infection 171 97.04 Very High Very High Very High
Brain Tumor 55 96.76 Very High Very High Very High
Adhesions 10 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, an increased expression of CTLA-4/CD152 was observed in eosinophils from infected donors.
Gene_expression (expression) of CD152 in eosinophils
1) Confidence 0.65 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.42 Pain Relevance 0.03
The Ctla4, Eda, and Mrgpre genes are in the signaling category but are not found in the OKDB.
Neg (not) Gene_expression (found) of Ctla4
2) Confidence 0.63 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.15 Pain Relevance 0.04
Likewise, CD69, CD71, as markers for T cell activation, as well as CD152 (CTLA-4) were found to be expressed only at low levels, and with no difference between patients and controls.
Neg (no) Gene_expression (expressed) of CTLA-4 in T cell
3) Confidence 0.59 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.37 Pain Relevance 0
Likewise, CD69, CD71, as markers for T cell activation, as well as CD152 (CTLA-4) were found to be expressed only at low levels, and with no difference between patients and controls.
Neg (no) Gene_expression (expressed) of CD152 in T cell
4) Confidence 0.59 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.37 Pain Relevance 0
While Ctla4 appears to be the real causal gene, other genes such as CD28, icos, slc11a1, irs1, and casp8 may also play roles in this important QTL, depending on different populations and genome backgrounds.
Gene_expression (appears) of Ctla4
5) Confidence 0.50 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.51 Pain Relevance 0
Three of the genes that we have included in Table 2 were not found in the OKdb: Mrgpre, Ctla4 and Eda.
Neg (not) Gene_expression (found) of Ctla4
6) Confidence 0.48 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.10 Pain Relevance 0
Unfortunately, the cell surface proteins on Tregs (for example; CD25, CTLA4) are also expressed on other immune cells such as activated T lymphocytes [46].
Gene_expression (expressed) of CTLA4 in T lymphocytes
7) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.73 Pain Relevance 0.05
Intracellular CTLA4 is expressed at high levels in Tregs and is also expressed at much lower levels on the cell surface of resting Tregs.
Gene_expression (expressed) of CTLA4
8) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.49 Pain Relevance 0.04
Intracellular CTLA4 is expressed at high levels in Tregs and is also expressed at much lower levels on the cell surface of resting Tregs.
Gene_expression (expressed) of CTLA4
9) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.54 Pain Relevance 0.04
The phenotype of CD4(+)CD25(+) Treg cells, including the expressions of CD44, CD45RB, CD62L, CD69, GITR and CTLA-4, did not show detectable changes in ASA-treated mice.
Gene_expression (expressions) of CTLA-4 associated with aspirin
10) Confidence 0.44 Published 2009 Journal Transpl. Immunol. Section Abstract Doc Link 19146957 Disease Relevance 0.21 Pain Relevance 0.69
CTLA4 is also expressed in the ER of helper and effector T lymphocytes and cell surface expression is upregulated 24 to 48 h after activation of TCR [48].
Gene_expression (expressed) of CTLA4 in effector T lymphocytes
11) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.51 Pain Relevance 0.04
Tregs are a subpopulation of CD4+ T lymphocytes that constitutively express the transcription factor Foxp3, the high affinity IL2 receptor CD25 and the B7 ligand CTLA4 [20].
Gene_expression (express) of CTLA4 in T lymphocytes
12) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 1.28 Pain Relevance 0.05
CTLA4 is a negative regulatory receptor that is expressed after stimulation and functions to limit T-cell responses.
Gene_expression (expressed) of CTLA4 in T-cell
13) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.15 Pain Relevance 0.21
Other polymorphic genes thought to be involved in RA include protein tyrosine phosphatase N22 (PTPN22), CTLA4, peptidyl arginine deiminase type IV and macrophage migration inhibitory factor (reviewed in [86]).
Gene_expression (include) of CTLA4 in macrophage associated with rheumatoid arthritis
14) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 1.38 Pain Relevance 0.52
The opposite is desirable in cancer treatment and the co-stimulatory pathway can be activated through blockade of CTLA4 and/or transfer of CD80/CD86 [85, 86].
Gene_expression (transfer) of CTLA4 in CD86 associated with immunotherapy of cancer
15) Confidence 0.17 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.79 Pain Relevance 0
Also, senescent CD4+ T cells express a number of new regulatory molecules instead of the traditional ones, such as CD28 and CTLA-4, that control their activation or inhibition.
Gene_expression (express) of CTLA-4 in T cells
16) Confidence 0.14 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 0.23 Pain Relevance 0
PD-1 is expressed by activated, but not unstimulated, T cells, B cells and myeloid cells, which is in contrast with the predominantly T-cell-restricted expression of CD28 and CTLA-4 [21-23].
Gene_expression (expression) of CTLA-4 in B cells
17) Confidence 0.13 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 0.86 Pain Relevance 0.39
Furthermore, IL-2 has been shown to upregulate CTLA-4 (cytotoxic T-lymphocyte-associated protein 4; CD152), and CTLA-4-deficienciy leads to a fatal lymphoproliferative disease that is more aggressive than the lymphoproliferative disorders caused by either IL-2 or Fas deficiency [35].
Gene_expression (cytotoxic) of T-lymphocyte-associated protein 4 in cytotoxic T-lymphocyte associated with lymphoproliferative disease
18) Confidence 0.11 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 1.57 Pain Relevance 0.18
and Th17 (IL-23/IL-17) responses related to increased expression of CTLA-4 and PD-1 [21].
Gene_expression (expression) of CTLA-4
19) Confidence 0.08 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 1.25 Pain Relevance 0.08
and Th17 (IL-23/IL-17) responses related to increased CTLA-4 and PD-1 expression (manuscript in press).
Gene_expression (expression) of CTLA-4
20) Confidence 0.08 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 1.81 Pain Relevance 0.06

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