INT157409

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.21
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf23) extracellular space (Fgf23)
Anatomy Link Frequency
fibroblast 2
Fgf23 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 5 87.72 High High
rheumatoid arthritis 4 84.88 Quite High
Fibrositis 1 57.20 Quite High
Neuropeptide 4 55.52 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
colic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 137 99.62 Very High Very High Very High
Fracture Healing 52 98.92 Very High Very High Very High
Hypophosphatemia 11 96.52 Very High Very High Very High
Kidney Stones 22 91.16 High High
Pain 5 87.72 High High
Rheumatoid Arthritis 4 84.88 Quite High
Familial Hypophosphatemia 9 82.40 Quite High
Confusion 1 73.72 Quite High
Disease 3 72.48 Quite High
Bone Cancer 1 66.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fact that 1,25(OH)2D3 upregulates FGF23 gene expression in bone [34] and undetectable serum levels of FGF23 are found in mice lacking the vitamin D receptor [35], downregulation of FGF23 in the OVX-D group could be explained by lack of dietary vitamin D.
Negative_regulation (downregulation) of FGF23
1) Confidence 0.50 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.34 Pain Relevance 0.05
Among genes with suggested or known roles in bone metabolism, fibroblast growth factor 23 (FGF23) was downregulated (P = 0.02) and interleukin 17 (IL-17) receptor A was upregulated (P = 0.01) in the OP group at 3 weeks.Fig. 3Differentially expressed genes in the OVX-D group.
Negative_regulation (downregulated) of FGF23 in fibroblast associated with osteoporosis
2) Confidence 0.50 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.23 Pain Relevance 0
Among genes with suggested or known roles in bone metabolism, fibroblast growth factor 23 (FGF23) was downregulated (P = 0.02) and interleukin 17 (IL-17) receptor A was upregulated (P = 0.01) in the OP group at 3 weeks.Fig. 3Differentially expressed genes in the OVX-D group.
Negative_regulation (downregulated) of fibroblast growth factor 23 in fibroblast associated with osteoporosis
3) Confidence 0.50 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.23 Pain Relevance 0
Thus, downregulation of FGF23 in our model could also be associated with a possible delay in fracture healing at an early stage, although this is not supported by our other findings.
Negative_regulation (downregulation) of FGF23 associated with fracture healing
4) Confidence 0.50 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.46 Pain Relevance 0.04
Compared to patients with normal bone status, patients with osteopenia and osteoporosis had significantly decreased FGF23 levels, whereas serum phosphate was identical in the two groups.
Negative_regulation (decreased) of FGF23 associated with osteoporosis
5) Confidence 0.50 Published 2009 Journal Calcif. Tissue Int. Section Abstract Doc Link 19148564 Disease Relevance 1.24 Pain Relevance 0.17
It could be hypothesized that downregulation of FGF23 serum levels, due to decreased phosphate reabsorption, could explain, at least partly, the elevation of the 1-25 vitamin D.
Negative_regulation (downregulation) of FGF23
6) Confidence 0.11 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2821378 Disease Relevance 0.71 Pain Relevance 0

General Comments

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