INT157416

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.28
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Samsn1) nucleus (Samsn1)
Anatomy Link Frequency
liver 3
NASh 1
hepatocytes 1
respiratory 1
Samsn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 15 91.72 High High
depression 4 86.88 High High
alcohol 41 79.36 Quite High
agonist 13 61.24 Quite High
fluoxetine 1 59.40 Quite High
Morphine 4 50.00 Quite Low
withdrawal 3 50.00 Quite Low
Dopamine 2 50.00 Quite Low
narcan 2 10.00 Low Low
Inflammation 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nash(non-alcoholic Steatohepatitis) 163 100.00 Very High Very High Very High
Fatty Liver 123 100.00 Very High Very High Very High
Stress 60 99.62 Very High Very High Very High
Death 10 99.36 Very High Very High Very High
Obesity 39 99.12 Very High Very High Very High
Disease Progression 3 98.52 Very High Very High Very High
Liver Disease 42 98.20 Very High Very High Very High
Hypoxia 196 93.56 High High
Injury 24 92.72 High High
Fibrosis 12 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When combined, the individual effects of D1 receptor activation in the NASh and VTA on the affective signs of precipitated morphine withdrawal resemble those seen with systemic administration.


Positive_regulation (activation) of NASh in NASh
1) Confidence 0.53 Published 2009 Journal Psychopharmacology (Berl.) Section Body Doc Link 19148621 Disease Relevance 0 Pain Relevance 0
Specifically, it is likely that under conditions of pathological stress, in this instance NASH, the bioenergetic demands on mitochondria are increased for repair and detoxification, while at the same time the threshold capacity of the respiratory chain complexes is limited.
Positive_regulation (increased) of NASH in respiratory associated with stress and nash(non-alcoholic steatohepatitis)
2) Confidence 0.22 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0.58 Pain Relevance 0.04
Therefore, when ATP synthesis is depressed this would increase the susceptibility of hepatocytes to cell death, especially when ATP needs are increased acutely in the NASH patient.
Positive_regulation (increased) of NASH in hepatocytes associated with nash(non-alcoholic steatohepatitis) and death
3) Confidence 0.22 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0.78 Pain Relevance 0.08
Interestingly, nitration of tyrosine has been reported to be increased in the livers of NASH patients [28] and ob/ob mice with severe steatosis [29].
Positive_regulation (increased) of NASH in livers associated with nash(non-alcoholic steatohepatitis) and obesity
4) Confidence 0.16 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0.29 Pain Relevance 0
Feeding a HFD for 16 weeks induced NASH-like pathology accompanied by elevated triacylglycerols, increased CYP2E1 (cytochrome P450 2E1) and iNOS (inducible nitric oxide synthase) protein, and significantly enhanced hypoxia in the pericentral region of the liver.
Positive_regulation (induced) of NASH in liver associated with nash(non-alcoholic steatohepatitis) and hypoxia
5) Confidence 0.16 Published 2008 Journal Biochemical Journal Section Abstract Doc Link PMC2637578 Disease Relevance 0.97 Pain Relevance 0
However, these data question the role of CYP2E1 in oxidative damage-induced disease progression and suggest a possibility that other P450 enzymes such as CYP4A isozymes elevated in NAFLD and NASH may be involved in the progression of fatty liver diseases.

8.

Positive_regulation (elevated) of NASH in liver associated with liver disease, fatty liver, nash(non-alcoholic steatohepatitis) and disease progression
6) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.66 Pain Relevance 0.21

General Comments

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