INT157430

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Context Info
Confidence 0.70
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 8.13
Pain Relevance 7.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ephb6) plasma membrane (Ephb6)
Anatomy Link Frequency
liver 1
brain 1
spleen 1
lung 1
gonadal fat pads 1
Ephb6 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 84 98.20 Very High Very High Very High
long-term potentiation 255 95.08 Very High Very High Very High
depression 19 91.76 High High
antidepressant 10 90.24 High High
Glutamate receptor 12 90.12 High High
Morphine 3 89.20 High High
spinal dorsal horn 150 88.96 High High
Pain 67 88.44 High High
nMDA receptor antagonist 9 86.24 High High
nMDA receptor 21 85.84 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 366 99.64 Very High Very High Very High
Manic Depressive Disorder 5 98.60 Very High Very High Very High
Anxiety Disorder 121 98.52 Very High Very High Very High
Dislocations 3 98.52 Very High Very High Very High
Obesity 50 95.36 Very High Very High Very High
Cognitive Disorder 26 95.32 Very High Very High Very High
Hypersensitivity Pneumonitis 140 93.20 High High
Shock 40 91.88 High High
Body Weight 20 91.84 High High
Depression 27 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ephrinB-EphB interaction is well known to mediate bidirectional signals that propagate into EphB-expressing cells (forward signaling) and ephrinB-expression cells (reverse signaling).
Gene_expression (expressing) of EphB
1) Confidence 0.70 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.38
Interaction between EphB receptors and GRIP or PICK-1 may instead affect membrane trafficking of the GluR2 subunit of AMPA receptors [48].
Gene_expression (receptors) of EphB
2) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.22
The EphB receptor blocking reagent EphB2-Fc chimera (2 ?
Gene_expression (receptor) of EphB
3) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.34
At week 6, MeP, RP and MP were significantly reduced in all three groups (p<0.001); compared to CT, O/A and C/A were associated with greater reductions in MeP (p<0.001 and p=0.004, respectively), in RP (p=0.028 and p=0.032, respectively) in MP (p<0.001 and p=0.002, respectively) and with significant improvement in BDI-II score (p=0.05 and p=0.04, respectively) and ADL value (p=0.04 and p=0.05, respectively).
Gene_expression (p<0.001) of MeP
4) Confidence 0.55 Published 2009 Journal Arch Gerontol Geriatr Section Abstract Doc Link 19150139 Disease Relevance 1.01 Pain Relevance 1.34
At week 6, MeP, RP and MP were significantly reduced in all three groups (p<0.001); compared to CT, O/A and C/A were associated with greater reductions in MeP (p<0.001 and p=0.004, respectively), in RP (p=0.028 and p=0.032, respectively) in MP (p<0.001 and p=0.002, respectively) and with significant improvement in BDI-II score (p=0.05 and p=0.04, respectively) and ADL value (p=0.04 and p=0.05, respectively).
Gene_expression (p=0.004) of MeP
5) Confidence 0.55 Published 2009 Journal Arch Gerontol Geriatr Section Abstract Doc Link 19150139 Disease Relevance 1.01 Pain Relevance 1.34
At week 6, MeP, RP and MP were significantly reduced in all three groups (p<0.001); compared to CT, O/A and C/A were associated with greater reductions in MeP (p<0.001 and p=0.004, respectively), in RP (p=0.028 and p=0.032, respectively) in MP (p<0.001 and p=0.002, respectively) and with significant improvement in BDI-II score (p=0.05 and p=0.04, respectively) and ADL value (p=0.04 and p=0.05, respectively).
Gene_expression (reduced) of MeP
6) Confidence 0.55 Published 2009 Journal Arch Gerontol Geriatr Section Abstract Doc Link 19150139 Disease Relevance 1.08 Pain Relevance 1.42
At week 6, MeP, RP and MP were significantly reduced in all three groups (p<0.001); compared to CT, O/A and C/A were associated with greater reductions in MeP (p<0.001 and p=0.004, respectively), in RP (p=0.028 and p=0.032, respectively) in MP (p<0.001 and p=0.002, respectively) and with significant improvement in BDI-II score (p=0.05 and p=0.04, respectively) and ADL value (p=0.04 and p=0.05, respectively).
Gene_expression (reductions) of MeP
7) Confidence 0.55 Published 2009 Journal Arch Gerontol Geriatr Section Abstract Doc Link 19150139 Disease Relevance 1.02 Pain Relevance 1.35
The spleen cells were taken from B6 and Fc?
Gene_expression (taken) of B6 in spleen
8) Confidence 0.05 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.06 Pain Relevance 0
Seven days after the first SR antigen exposure, the immune cells in the lung tissues of B6 and Fc?
Gene_expression (tissues) of B6 in lung
9) Confidence 0.05 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.56 Pain Relevance 0.12
Thus, while B6 subjects expressed enhanced freezing responses following pre-exposure to object distress, we cannot rule out the possibility that BALB mice may also express empathy.
Gene_expression (expressed) of B6
10) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2633046 Disease Relevance 0.13 Pain Relevance 0.17
B6 subjects expressed longer freezing responses than BALB subjects after exposure to objects receiving the CS-UCS contingency (Fig. 3a; effect of subject genotype, F[1,124]?
Gene_expression (expressed) of B6
11) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2633046 Disease Relevance 0.28 Pain Relevance 0
Following pre-exposure to distressed object mice, B6 subjects also expressed enhanced acquisition of conditioned fear (relative to other groups) during the test trials in which they were directly exposed to the paired CS-UCS contingency (test trials 7-10).
Gene_expression (expressed) of B6 associated with anxiety disorder
12) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2633046 Disease Relevance 0.34 Pain Relevance 0
B6 subjects therefore expressed enhanced freezing in response to the CS even though they had not directly experienced the CS-UCS association themselves.
Gene_expression (expressed) of B6
13) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2633046 Disease Relevance 0.27 Pain Relevance 0
Among 29 genes residing within the 8.8-Mb region, Gpd2, Upp2, Acvr1c, March7 and Rbms1 showed great differential expression in livers and/or gonadal fat pads between B6.Cg-Pbwg1 and B6 mice.


Gene_expression (expression) of B6 in gonadal fat pads
14) Confidence 0.03 Published 2010 Journal BMC Genet Section Abstract Doc Link PMC2955677 Disease Relevance 0.87 Pain Relevance 0
We compared expression of the MMUX GABAA receptor subunit genes Gabra3, Gabre, and Gabrq, in hippocampal tissue from the NZB, B6, and R3 strains.
Gene_expression (expression) of B6 associated with sprains and strains
15) Confidence 0.02 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.42 Pain Relevance 0.11
In contrast, expression of more proximal coding exons (probe set 1449183_at) is not as strongly cis-regulated, is more variable across brain regions and organs, and is usually associated with higher expression from the B6 (B) allele (Fig. 1B).
Gene_expression (expression) of B6 in brain
16) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.09 Pain Relevance 0.03
A genetic reference population of B6 X D2 (BXD) recombinant inbred lines made by crossing these parental strains has been used extensively to explore differences in gene expression, neuropharmacology, and behavior, often using quantitative trait locus (QTL) mapping methods [11], [12].
Gene_expression (made) of B6 associated with sprains and strains
17) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.61 Pain Relevance 0.32
Naive B6, D2, BXD31, BXD76, B6D2F1, D2B6F1, A/J, LG/J, PWK/PhJ, and KK/HlJ mice were killed at about 60 days of age by cervical dislocation.The liver was immediately collected and stored in RNALater (Ambion) at 4°C overnight.
Gene_expression (killed) of B6 in liver associated with dislocations
18) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.36 Pain Relevance 0

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