INT15745

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Context Info
Confidence 0.43
First Reported 1988
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 8.01
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GYPA) molecular_function (GYPA) cellular_component (GYPA)
biological_process (GYPA)
Anatomy Link Frequency
skeletal muscle 4
liver 1
lymphocytes 1
cleavage 1
Mns 1
GYPA (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 8 100.00 Very High Very High Very High
lidocaine 4 100.00 Very High Very High Very High
Dopamine 156 98.94 Very High Very High Very High
monoamine 12 97.00 Very High Very High Very High
antagonist 6 96.52 Very High Very High Very High
Analgesic 3 96.20 Very High Very High Very High
withdrawal 2 92.64 High High
Chronic pancreatitis 9 92.12 High High
Angina 2 90.96 High High
Multiple sclerosis 11 85.80 High High
Disease Link Frequency Relevance Heat
Depression 8 100.00 Very High Very High Very High
Aging 303 99.76 Very High Very High Very High
Neurodegenerative Disease 12 99.74 Very High Very High Very High
Chromosome Aberrations 1 99.20 Very High Very High Very High
Heart Rate Under Development 10 98.36 Very High Very High Very High
Stress 86 96.56 Very High Very High Very High
Disease 198 92.96 High High
Pancreatitis 9 92.12 High High
Cv General 3 Under Development 2 90.96 High High
Dilated Cardiomyopathy 2 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that the initial inhibition exerted on the HD-Mns, by delaying the excitation of Mns, may play a role in the nervous mechanisms involved in temporal organization of the swallowing motor sequence.
Negative_regulation (inhibition) of Mns in Mns
1) Confidence 0.43 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9065858 Disease Relevance 0.17 Pain Relevance 0.06
IS-5-MN the mean ST- segment depression under comparable load was reduced by 67% 2 h p.a. and by 70% 10 h p.a.
Negative_regulation (reduced) of IS-5-MN associated with depression
2) Confidence 0.31 Published 1991 Journal Cardiology Section Abstract Doc Link 1760831 Disease Relevance 0.47 Pain Relevance 0.29
The reduction under the 80 mg IS-5-MN form was about 76% 2 h p.a. and 78% 10 h p.a.
Negative_regulation (reduction) of IS-5-MN
3) Confidence 0.31 Published 1991 Journal Cardiology Section Abstract Doc Link 1760831 Disease Relevance 0.49 Pain Relevance 0.30
To determine whether nitration was related to the decline of Mn-SOD activity in the SO group, Mn-SOD nitration was evaluated following immuno-precipitation of Mn-SOD.
Spec (whether) Negative_regulation (decline) of Mn-SOD
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.15 Pain Relevance 0
Since aging in skeletal muscle is widely related to increases in O-.2 production via mitochondrial ETC, we suggest that physical activity maintains mitochondrial Mn-SOD activity in AO individuals at levels observed in much younger individuals despite significant reductions in the Mn-SOD protein content.


Negative_regulation (reductions) of Mn-SOD in skeletal muscle associated with aging
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.29 Pain Relevance 0
This finding suggests that the Ile58Thr polymorphism may be associated with neurodegenerative diseases involving a decrease in Mn-SOD levels [15].
Negative_regulation (decrease) of Mn-SOD associated with neurodegenerative disease
6) Confidence 0.23 Published 2001 Journal BMC Med Genet Section Body Doc Link PMC31388 Disease Relevance 0.82 Pain Relevance 0.03
Myrcene was tested up to 1,000 micrograms/ml (limit of solubility) in the presence and absence of S9-mix and did not induce chromosome aberrations and sister chromatid exchanges (SCEs) in human lymphocytes in vitro.
Negative_regulation (absence) of S9-mix in lymphocytes associated with chromosome aberrations
7) Confidence 0.22 Published 1991 Journal Environ. Mol. Mutagen. Section Abstract Doc Link 1864266 Disease Relevance 0.10 Pain Relevance 0.19
We hypothesized that physical inactivity-associated dysregulation in mitochondrial COX activity may result in aberrant formation of free radicals, i.e., O-.2, OH., ONOO-, etc., via activation of NOS content, thus producing pathological levels of NO and causing inactivation of Mn-SOD in the skeletal muscle of the frail old subjects.
Negative_regulation (inactivation) of Mn-SOD in skeletal muscle
8) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.76 Pain Relevance 0.10
Together, these observations suggest that Mn-SOD activity in the skeletal muscle is maintained with a physically active lifestyle, and that sedentary lifestyle-mediated mitochondrial ETC dysregulation makes the intracellular environment more conducive to pro-oxidant production, resulting in the inactivation of Mn-SOD, insufficient dismutation of O2- radical and mitochondrial redox crisis.
Negative_regulation (inactivation) of Mn-SOD in skeletal muscle
9) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 1.01 Pain Relevance 0.12
Inactivation of Mn-SOD activity leads to futile cycling of O-.2, resulting in an amplification of oxidative stress [69].
Negative_regulation (Inactivation) of Mn-SOD associated with stress
10) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.10 Pain Relevance 0
The mitochondrial antioxidant enzyme milieu of active older adults provides an intra-organellar environment conducive to O-.2 dismutation via maintenance of their Mn-SOD activity at levels similar to those found in young subjects, despite an aging-associated decline in Mn-SOD content in skeletal muscle.
Negative_regulation (decline) of Mn-SOD in skeletal muscle associated with aging
11) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.69 Pain Relevance 0.08
We observed a significant reduction in both Mn-SOD protein content and activity in the SO adults relative to both the AO and young adults (Figures 3A and 3B).
Negative_regulation (reduction) of Mn-SOD
12) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.23 Pain Relevance 0
Interestingly, Mn-SOD activity was preserved in the AO adults, despite a significant reduction in their Mn-SOD content compared to the young (Figure 3B).
Negative_regulation (preserved) of Mn-SOD
13) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.23 Pain Relevance 0
Interestingly, Mn-SOD activity was preserved in the AO adults, despite a significant reduction in their Mn-SOD content compared to the young (Figure 3B).
Negative_regulation (reduction) of Mn-SOD
14) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.23 Pain Relevance 0
In addition, inefficient cleavage of a particular signal may reduce the level of enzymatic activity of an imported protein, such as Mn-SOD, within the mitochondrial compartment [30].
Spec (may) Negative_regulation (reduce) of Mn-SOD in cleavage
15) Confidence 0.15 Published 2001 Journal BMC Med Genet Section Body Doc Link PMC31388 Disease Relevance 0.36 Pain Relevance 0.03
This procedure was not performed by Eriksson et al. (1992a); thus, the effect of Mn on the [3H]-mazindol autoradiography results were a combination of DAT and other monoaminergic uptake sites. c) As pointed out, even if [3H]-mazindol was made selective for DAT by including antagonists for other monoaminergic transporters, a reduction in [3H]-mazindol binding to DAT would not necessarily reflect dopamine terminal loss, but it could represent a competitive inhibition of Mn with radioligand binding to DAT as shown by Chen et al. (2006).
Negative_regulation (inhibition) of Mn associated with dopamine, antagonist and monoamine
16) Confidence 0.12 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0 Pain Relevance 0.38
Consistent with this hypothesis, a direct inhibitory effect of Mn on radioligand binding to DAT was demonstrated in the same study.
Negative_regulation (effect) of Mn
17) Confidence 0.12 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.22 Pain Relevance 0.22
Blockade of neural traffic (by lidocaine) in the MnPO produced an attenuation of AVP-mediated bradycardia but not the baroreflex-mediated bradycardia caused by PE.
Negative_regulation (Blockade) of MnPO in neural associated with heart rate under development and lidocaine
18) Confidence 0.04 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3381901 Disease Relevance 0.77 Pain Relevance 0.42
We used the macaque model to test the efficacy of a novel combination microbicide gel containing zinc acetate and micromolar doses of the novel non-nucleoside reverse transcriptase inhibitor MIV-150 for up to 24 h after repeated gel application.


Negative_regulation (inhibitor) of MIV-150
19) Confidence 0.03 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3016413 Disease Relevance 0.33 Pain Relevance 0
Pre- and postperfusion liver glycogen contents revealed comparable decreases in liver glycogen in both groups: insulin inhibition of HGP in sham rats was accompanied by higher postperfusion glycogen content.
Negative_regulation (inhibition) of HGP in liver
20) Confidence 0.00 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2654478 Disease Relevance 0.58 Pain Relevance 0.53

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