INT157461

Context Info Confidence 0.36 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 5 Disease Relevance 6.72 Pain Relevance 2.67

cell adhesion (CX3CR1) plasma membrane (CX3CR1) signal transducer activity (CX3CR1)

Anatomy Link Frequency monocytes 1 anterior 1 natural killer cells 1 T cell 1 CX3CR1 (Homo sapiens)

Pain Link Frequency Relevance Heat glial activation 1 99.10 Neuropathic pain 1 98.60 Inflammation 73 98.28 rheumatoid arthritis 6 97.08 Chronic pancreatitis 9 96.96 chemokine 169 96.62 fibrosis 4 95.08 psoriasis 3 94.16 Inflammatory stimuli 1 92.64 Neuritis 5 88.16

Disease Link Frequency Relevance Heat Neuropathic Pain 1 98.60 Adhesions 2 98.48 INFLAMMATION 88 98.28 Disease 74 97.76 Rheumatoid Arthritis 15 97.08 Pancreatitis 9 96.96 Asthma 6 96.20 Fibrosis 6 95.08 Psoriasis 3 94.16 Renal Disease 3 93.72

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, fractalkine increases neuropathic pain through glial activation, which can be diminished by blocking of its receptor, CX3CR1, through neutralizing antibodies.

CX3CR1 Binding (receptor) of associated with neuropathic pain and glial activation

1) Confidence 0.36 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 1.62 Pain Relevance 1.35

It interacts with the unique receptor CX3CR1 that is expressed on monocytes, natural killer cells, and some T cells.

CX3CR1 Binding (interacts) of in natural killer cells

2) Confidence 0.32 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.58 Pain Relevance 0.31

Fractalkine/CX3CL1-CX3CR1 interaction contributes to the development of various inflammatory diseases such as rheumatoid arthritis, asthma, Wegener’s granulomatosis, Crohn’s disease, psoriasis, glomerulonephritis, experimental autoimmune anterior uveitis, and atherosclerosis [52-57].

CX3CR1 Binding (interaction) of in anterior associated with psoriasis, renal disease, rheumatoid arthritis, increased venous pressure under development, disease, asthma, inflammation and uveitis

3) Confidence 0.24 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.61 Pain Relevance 0.28

It interacts with the unique receptor CX3CR1 that is expressed on monocytes, natural killer cells, and some T cells.

CX3CR1 Binding (interacts) of in monocytes

4) Confidence 0.11 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.58 Pain Relevance 0.31

Lastly, the “CX3C” chemokines (three amino acids between the first two cysteines) are, to date, represented by a single peptide, namely, CX3CL1/fractalkine, which is encoded on human chromosome 16, binds the CX3CR1 receptor and regulates T cell trafficking and adhesion [4].

CX3CR1 receptor Binding (binds) of in T cell associated with chemokine and adhesions

5) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.34 Pain Relevance 0.43

General Comments

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