INT157462

Context Info Confidence 0.42 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.62 Pain Relevance 1.36

cell adhesion (CX3CR1) plasma membrane (CX3CR1) signal transducer activity (CX3CR1)

CX3CR1 (Homo sapiens)

Pain Link Frequency Relevance Heat glial activation 1 99.42 Neuropathic pain 1 98.92 Chronic pancreatitis 9 96.96 fibrosis 4 95.72 Inflammation 6 94.64 chemokine 1 90.32 Neuritis 5 88.16 Pain 6 86.56 Visceral pain 1 25.00

Disease Link Frequency Relevance Heat Neuropathic Pain 1 98.92 Pancreatitis 9 96.96 Fibrosis 6 95.72 INFLAMMATION 6 94.64 Neuritis 5 88.16 Pain 5 86.56 Hypertrophy 1 63.84 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, fractalkine increases neuropathic pain through glial activation, which can be diminished by blocking of its receptor, CX3CR1, through neutralizing antibodies.

Negative_regulation (blocking) of CX3CR1 Binding (receptor) of associated with neuropathic pain and glial activation

1) Confidence 0.42 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19153557 Disease Relevance 1.62 Pain Relevance 1.36

General Comments

This test has worked.